Assessment for 11q and other chromosomal aberrations in large B-cell/high-grade B cell lymphomas of germinal center phenotype lacking BCL2 expression

• Published in: Cancer genetics 2024-06, Vol.284-285, p.30-33
• Main Authors: Ho, Chia-Chen, Naresh, Kikkeri, Liu, Yajuan, Wu, Yu, Gopal, Ajay K, Eckel, Ashley M
• Format: Article
• Language: English
• Subjects: 11q; Burkitt; Dlbcl; Lymphoma; Microarray
• ISSN: 2210-7762; 2210-7770
• DOI: 10.1016/j.cancergen.2024.03.001

•Per author guidelines, highlights appear to be for full research articles.•This study utilized genomic array to assess for chromosome 11q abnormalities in a broad set of aggressive B cell lymphomas.•Findings suggest a higher frequency of any chromosome 11q abnormality in DLBCL/HGBCL-GC BCL2- in comparison to cases of BL and DLBCL-GC BCL2+.•Findings suggest genomic array studies may afford value over FISH testing as we continue to understand HGBCL-11q as a distinct entity. The WHO classifications of hematolymphoid malignancies have recognized several distinct entities within the large B cell lymphomas, including the more recently described high-grade B cell lymphoma with 11q aberration (HGBCL-11q). We utilized genomic array to assess for chromosome 11q abnormalities in a broad set of aggressive B cell lymphomas from 27 patients with a focus on younger adults. The findings suggest more frequent alterations of 11q in diffuse large B cell lymphoma (DLBCL)/HGBCL-GC BCL2-, in comparison to cases of Burkitt lymphoma (BL) or DLBCL-GC BCL2+, and confirm a low genomic complexity score of BL. Variability identified in patterns of 11q alterations suggests genomic array studies may afford value over FISH testing as we continue to understand HGBCL-11q as a distinct entity, and interrogate cases of DLBCL/HGBCL-GC BCL2-.