Mesoporous Silica Nanoparticles for Drug Delivery and Biosensing Applications

Recent advancements in morphology control and surface functionalization of mesoporous silica nanoparticles (MSNs) have enhanced the biocompatibility of these materials with high surface areas and pore volumes. Several recent reports have demonstrated that the MSNs can be efficiently internalized by...

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Bibliographic Details
Published in:Advanced functional materials 2007-05, Vol.17 (8), p.1225-1236
Main Authors: Slowing, I. I., Trewyn, B. G., Giri, S., Lin, V. S.-Y.
Format: Article
Language:English
Subjects:
Biosensors
Controlled release
Drug delivery
Mesoporous materials
Nanoparticles
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Summary:Recent advancements in morphology control and surface functionalization of mesoporous silica nanoparticles (MSNs) have enhanced the biocompatibility of these materials with high surface areas and pore volumes. Several recent reports have demonstrated that the MSNs can be efficiently internalized by animal and plant cells. The functionalization of MSNs with organic moieties or other nanostructures brings controlled release and molecular recognition capabilities to these mesoporous materials for drug/gene delivery and sensing applications, respectively. Herein, we review recent research progress on the design of functional MSN materials with various mechanisms of controlled release, along with the ability to achieve zero release in the absence of stimuli, and the introduction of new characteristics to enable the use of nonselective molecules as screens for the construction of highly selective sensor systems. Mesoporous silica nanoparticles (MSNs) with controlled morphology and porosity can be chemically functionalized to serve as intracellular delivery vehicles for the controlled release of drugs and genes (see figure), and for the selective detection of biomolecules. Research progress on the design of functional MSN materials with various mechanisms of controlled release is reviewed.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.200601191