Marrow Fat-Cortical Bone Relationship in β-Thalassemia: A Study Using MRI

Growing evidence suggests that marrow adipocytes play an active role in the regulation of bone metabolism and hematopoiesis. However, research on the relationship between bone and fat in the context of hematological diseases, particularly β-thalassemia, remains limited. To investigate the relationsh...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2024-12, Vol.60 (6), p.2447-2456
Main Authors: Ismail, Umi Nabilah, Azlan, Che Ahmad, Khairullah, Shasha, Azman, Raja Rizal, Omar, Nur Farhayu, Md Shah, Mohammad Nazri, Jackson, Nicholas, Ng, Kwan Hoong
Format: Article
Language:English
Subjects:
Adipocytes
Adipose Tissue - diagnostic imaging
Adipose Tissue - pathology
Adolescent
Adult
beta-Thalassemia - complications
beta-Thalassemia - diagnostic imaging
Blood diseases
Body mass index
Body size
Bone composition
Bone marrow
Bone Marrow - diagnostic imaging
Bone Marrow - pathology
Bone turnover
Correlation
Cortical bone
Cortical Bone - diagnostic imaging
Cortical Bone - pathology
Diaphysis
Disease control
Fat metabolism
Female
Femur
Femur - diagnostic imaging
Femur - pathology
Field strength
Hematological diseases
Hematopoiesis
Hemopoiesis
Humans
Magnetic Resonance Imaging - methods
Male
Males
Multiple regression models
Prospective Studies
Proton density (concentration)
Regression analysis
Sex
Statistical analysis
Statistical tests
Thalassemia
Thickness
Trochanter
Variance analysis
Young Adult
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Summary:Growing evidence suggests that marrow adipocytes play an active role in the regulation of bone metabolism and hematopoiesis. However, research on the relationship between bone and fat in the context of hematological diseases, particularly β-thalassemia, remains limited. To investigate the relationship between marrow fat and cortical bone thickness in β-thalassemia and to identify key determinants influencing these variables. Prospective. Thirty-five subjects in four subject groups of increasing disease severity: 6 healthy control (25.0 ± 5.3 years, 2 male), 4 β-thalassemia minor, 13 intermedia, and 12 major (29.1 ± 6.4 years, 15 male). 3.0 T, 3D fast low angle shot sequence and T -weighted turbo spin echo. Analyses on proton density fat fraction (PDFF) and R * values in femur subregions (femoral head, greater trochanter, intertrochanteric, diaphysis, distal) and cortical thickness (CBI) of the subjects' left femur. Clinical data such as age, sex, body mass index (BMI), and disease severity were also included. One-way analysis of variance (ANOVA), mixed ANOVA, Pearson correlation and multiple regression. P-values
ISSN:1053-1807
1522-2586
1522-2586
DOI:10.1002/jmri.29366