Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

Spliceosome machinery mutations are common early mutations in myeloid malignancies; however, effective targeted therapies against them are still lacking. In the current study, we used an in vitro high-throughput drug screen among four different isogenic cell lines and identified RKI-1447, a Rho-asso...

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Published in:iScience 2024-04, Vol.27 (4), p.109443, Article 109443
Main Authors: Su, Minhua, Fleischer, Tom, Grosheva, Inna, Horev, Melanie Bokstad, Olszewska, Malgorzata, Mattioli, Camilla Ciolli, Barr, Haim, Plotnikov, Alexander, Carvalho, Silvia, Moskovich, Yoni, Minden, Mark D., Chapal-Ilani, Noa, Wainstein, Alexander, Papapetrou, Eirini P., Dezorella, Nili, Cheng, Tao, Kaushansky, Nathali, Geiger, Benjamin, Shlush, Liran I.
Format: Article
Language:English
Subjects:
Cancer
Cell biology
Molecular biology
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