Application of Machine Learning for Classification of Brain Tumors: A Systematic Review and Meta-Analysis

• Published in: World neurosurgery 2024-06, Vol.186, p.204-218.e2
• Main Authors: Silva Santana, Laís, Borges Camargo Diniz, Jordana, Mothé Glioche Gasparri, Luisa, Buccaran Canto, Alessandra, Batista dos Reis, Sávio, Santana Neville Ribeiro, Iuri, Gadelha Figueiredo, Eberval, Paulo Mota Telles, João
• Format: Article
• Language: English
• Subjects: Brain Neoplasms - classification; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - pathology; Brain tumors; Classification; Glioblastoma - classification; Glioblastoma - diagnostic imaging; Glioblastoma - pathology; Glioma - classification; Glioma - diagnostic imaging; Glioma - pathology; Humans; Machine Learning; Sensitivity and Specificity
• ISSN: 1878-8750; 1878-8769; 1878-8769
• DOI: 10.1016/j.wneu.2024.03.152

Classifying brain tumors accurately is crucial for treatment and prognosis. Machine learning (ML) shows great promise in improving tumor classification accuracy. This study evaluates ML algorithms for differentiating various brain tumor types. A systematic review and meta-analysis were conducted, searching PubMed, Embase, and Web of Science up to March 14, 2023. Studies that only investigated image segmentation accuracy or brain tumor detection instead of classification were excluded. We extracted binary diagnostic accuracy data, constructing contingency tables to derive sensitivity and specificity. Fifty-one studies were included. The pooled area under the curve for glioblastoma versus lymphoma and low-grade versus high-grade gliomas were 0.99 (95% confidence interval [CI]: 0.98–1.00) and 0.89, respectively. The pooled sensitivity and specificity for benign versus malignant tumors were 0.90 (95% CI: 0.85–0.93) and 0.93 (95% CI: 0.90–0.95), respectively. The pooled sensitivity and specificity for low-grade versus high-grade gliomas were 0.99 (95% CI: 0.97–1.00) and 0.94, (95% CI: 0.79–0.99), respectively. Primary versus metastatic tumor identification yields sensitivity and specificity of 0.89, (95% CI: 0.83–0.93) and 0.87 (95% CI: 0.82–0.91), correspondingly. The differentiation of gliomas from pituitary tumors yielded the highest results among primary brain tumor classifications: sensitivity of 0.99 (95% CI: 0.99–1.00) and specificity of 0.99 (95% CI: 0.98–1.00). ML demonstrated excellent performance in classifying brain tumor images, with near-maximum area under the curves, sensitivity, and specificity.