Lower serum uric acid to serum creatinine ratio as a predictor of poor functional outcome after mechanical thrombectomy in acute ischaemic stroke

Background and purpose The ratio of serum uric acid (SUA) to serum creatinine (SCr), representing normalized SUA for renal function, is associated with functional outcome in acute ischaemic stroke (AIS) patients. However, its effect on AIS patients undergoing mechanical thrombectomy (MT) remains unk...

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Published in:European journal of neurology 2024-07, Vol.31 (7), p.e16296-n/a
Main Authors: Xu, Jinghan, Jiang, Xin, Liu, Qian, Liu, Jiaxin, Fang, Jinghuan, He, Li
Format: Article
Language:English
Subjects:
acute ischaemic stroke
Aged
Aged, 80 and over
clinical outcome
Creatinine
Creatinine - blood
Female
Hemorrhage
Humans
Ischemia
Ischemic Stroke - blood
Ischemic Stroke - surgery
Ischemic Stroke - therapy
Male
mechanical thrombectomy
Middle Aged
Prognosis
Recovery of Function - physiology
Renal function
Retrospective Studies
serum uric acid to serum creatinine ratio
Stroke
stroke severity
Thrombectomy
Treatment Outcome
Uric acid
Uric Acid - blood
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Summary:Background and purpose The ratio of serum uric acid (SUA) to serum creatinine (SCr), representing normalized SUA for renal function, is associated with functional outcome in acute ischaemic stroke (AIS) patients. However, its effect on AIS patients undergoing mechanical thrombectomy (MT) remains unknown. This study aimed to investigate the influence of the SUA/SCr ratio on clinical outcome in MT‐treated AIS patients. Methods Acute ischaemic stroke patients who underwent MT were continuously enrolled from January 2018 to June 2023. Upon admission, SUA and SCr levels were recorded within the initial 24 h. Stroke severity was determined using the National Institutes of Health Stroke Scale (NIHSS) score. Clinical outcome included poor functional outcome (modified Rankin Scale score >2) at 90 days, symptomatic intracranial haemorrhage and death. Results Amongst 734 patients, 432 (58.8%) exhibited poor functional outcome at 90 days. The SUA/SCr ratio exhibited a negative correlation with NIHSS score (ρ = −0.095, p = 0.010). Univariate analysis revealed a significant association between SUA/SCr ratio and poor functional outcome. After adjusting for confounders, the SUA/SCr ratio remained an independent predictor of functional outcome (adjusted odds ratio 0.348, 95% confidence interval 0.282–0.428, p 
ISSN:1351-5101
1468-1331
1468-1331
DOI:10.1111/ene.16296