Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

Inflammation in ulcerative colitis is typically restricted to the mucosal layer of distal gut. Disrupted mucus barrier, coupled with microbial dysbiosis, has been reported to occur prior to the onset of inflammation. Here, we show the involvement of vesicular trafficking protein Rab7 in regulating t...

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Bibliographic Details
Published in:	eLife 2024-04, Vol.12
Main Authors:	Gaur, Preksha, Rajendran, Yesheswini, Srivastava, Bhagyashree, Markandey, Manasvini, Fishbain-Yoskovitz, Vered, Mohapatra, Gayatree, Suhail, Aamir, Chaudhary, Shikha, Tyagi, Shaifali, Yadav, Subhash Chandra, Pandey, Amit Kumar, Merbl, Yifat, Bajaj, Avinash, Ahuja, Vineet, Srikanth, Chittur
Format:	Article
Language:	English
Subjects:	Animals Biopsy Chloride channels (calcium-gated) Chloride Channels - genetics Chloride Channels - metabolism CLCA1 Colitis - chemically induced Colitis - metabolism Colon Colon - metabolism Crohn's disease Dextran Digestive system Disease Models, Animal Drinking water Dysbacteriosis Gastrointestinal tract Goblet cells Goblet Cells - metabolism Homeostasis Humans Immunology and Inflammation Inflammation Inflammation - metabolism Inflammatory bowel disease Intestinal microflora Intestinal Mucosa - metabolism Lysosomes Mice Mice, Inbred C57BL Microbiota Mucosa Mucus Pathogenesis Patients Permeability Protein transport Proteins Proteomics Rab7 GTPase Statistical analysis Ulcerative colitis
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