The efficacy and safety of ciprofol and propofol in patients undergoing colonoscopy: A double-blind, randomized, controlled trial

• Published in: Journal of clinical anesthesia 2024-08, Vol.95, p.111474, Article 111474
• Main Authors: Gao, Shi-Hui, Tang, Qian-Qian, Wang, Chang-Ming, Guan, Zhan-Ying, Wang, Ling-Ling, Zhang, Jing, Yan, Zeng-Long
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anesthesia; Anesthesia Recovery Period; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - adverse effects; Benzodiazepines; Body mass index; Ciprofol; Colonoscopy; Colonoscopy - adverse effects; Colonoscopy - methods; Conscious Sedation - adverse effects; Conscious Sedation - methods; Double-Blind Method; Drug dosages; Female; Heart rate; Humans; Hypertension; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - adverse effects; Male; Middle Aged; Narcotics; Operative Time; Patient Satisfaction; Patients; Propofol; Propofol - administration & dosage; Propofol - adverse effects; Sedation; Treatment Outcome; Vital signs
• ISSN: 0952-8180; 1873-4529; 1873-4529
• DOI: 10.1016/j.jclinane.2024.111474

Propofol is a commonly utilized anesthetic for painless colonoscopy, but its usage is occasionally limited due to its potential side effects, including cardiopulmonary suppression and injection pain. To address this limitation, the novel compound ciprofol has been proposed as a possible alternative for propofol. This study sought to determine whether there are any differences in the safety and efficacy of propofol and ciprofol for painless colonoscopy. Randomized clinical trial. Single-centre, class A tertiary hospital, November 2021 to November 2022. Adult, American Society of Anesthesiologists Physical Status I to II and body mass index of 18 to 30 kg m−2 patients scheduled to undergo colonoscopy. Consecutive patients were randomly allocated in a 1:1 ratio to receive sedation for colonoscopy with ciprofol (group C) or propofol (group P). The primary outcome was the success rate of colonoscopy. The secondary outcomes were onset time of sedation, operation time, recovery time and discharge time, patients and endoscopists satisfaction, side effects (e.g. injection pain, myoclonus, drowsiness, dizziness, procedure recall, nausea and vomiting) and incidence rate of cardiopulmonary adverse events. No significant difference was found in the success rate of colonoscopy between the two groups (ciprofol 96.3% vs. propofol 97.6%; mean difference − 1.2%, 95% CI: −6.5% to 4.0%, P = 0.650). However, group C showed prolonged sedation (63.4 vs. 54.8 s, P