Elemental and Chemical Phase Analyses of Ras-Family Ayurvedic Medicinal Products

• Published in: Biological trace element research 2023-06, Vol.201 (6), p.3099-3116
• Main Authors: Duggal, Heena, Singh, Gurjot, Kapil, Ashutosh, Mehta, D., Kumar, Sanjeev
• Format: Article
• Language: English
• Subjects: Alternative medicine; Ayurvedic medicine; Bioavailability; Biochemistry; Biomedical and Life Sciences; Biotechnology; Dietary minerals; Elements; family; Fluorescence; Ingredients; Investigations; Lead; Lead oxides; Lead poisoning; Life Sciences; Manufacturers; Medical sciences; Medicine, Ayurvedic; Mercury; Mercury (metal); Mercury - analysis; Mercury Compounds; Nutrition; Oncology; Physics; Quality control; ras Proteins - metabolism; toxic substances; Toxicology; Wavelength; X ray fluorescence analysis; X ray powder diffraction; X rays; X-radiation; X-ray diffraction; X-ray fluorescence
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-022-03389-y

Fifteen Ayurvedic medicines of Ras-family (herbo-mineral-metallic preparations) from three reputed manufactures were analysed for elemental quantification and their chemical phase identification using the energy-dispersive (ED) and wavelength-dispersive (WD) X-ray fluorescence (XRF) techniques, and powder X-ray diffraction (XRD) technique, respectively. The low-Z elements C, H, N, S and O constituting a major portion of these medicines were also determined by CHNSO analyser and further used as input for XRF analyses. The elements of concern, Hg, Pb and As, are identified in different medicine products with disquiet concentration values (maximum concentration values range ~ 4–10%) and that too with substantial variations in the products from different manufacturers. These elements are identified mainly in the cinnabar (α-HgS)/metacinnabar (β-HgS), litharge (PbO) and alacranite (As 4 S 4 ) phases in different medicines. Keeping in view the high concentration of chemicals of the Hg, Pb and As elements in the Ras-family medicines, it is vitally required to investigate their bioaccessibility and surmise the associated toxicological aspects. It is suggested that the formation of the bioaccessible toxic chemical forms of the Hg, Pb and As elements be avoided during preparation of the mineral ingredients or these soluble chemical forms be removed at suitable stage of the preparation. In view of large variations observed for the Hg, Pb and As based ingredients in the Ras family Ayurvedic medicine products from different manufacturers, adequate quality control mechanisms and production regulations are recommended.