Multifunctional Metal–Phenolic Composites Promote Efficient Periodontitis Treatment via Antibacterial and Osteogenic Properties

Periodontitis, a complex inflammatory disease initiated by bacterial infections, presents a significant challenge in public health. The increased levels of reactive oxygen species and the subsequent exaggerated immune response associated with periodontitis often lead to alveolar bone resorption and...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2024-03, Vol.16 (11), p.13573-13584
Main Authors: Mei, Hongxiang, Liu, Hai, Sha, Chuanlu, Lv, Qinyi, Song, Qiantao, Jiang, Linli, Tian, Erkang, Gao, Ziqi, Li, Juan, Zhou, Jiajing
Format: Article
Language:English
Subjects:
animal models
Biological and Medical Applications of Materials and Interfaces
bone formation
bone marrow
bone morphogenetic proteins
bone resorption
immune response
inflammation
nanogold
nanoparticles
oxidative stress
periodontitis
public health
reactive oxygen species
therapeutics
tissue repair
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Summary:Periodontitis, a complex inflammatory disease initiated by bacterial infections, presents a significant challenge in public health. The increased levels of reactive oxygen species and the subsequent exaggerated immune response associated with periodontitis often lead to alveolar bone resorption and tooth loss. Herein, we develop multifunctional metal–phenolic composites (i.e., Au@MPN-BMP2) to address the complex nature of periodontitis, where gold nanoparticles (AuNPs) are coated by metal–phenolic networks (MPNs) and bone morphogenetic protein 2 (BMP2). In this design, MPNs exhibit remarkable antibacterial and antioxidant properties, and AuNPs and BMP2 promote osteogenic differentiation of bone marrow mesenchymal stem cells under inflammatory conditions. In a rat model of periodontitis, treatment with Au@MPN-BMP2 leads to notable therapeutic outcomes, including mitigated oxidative stress, reduced progression of inflammation, and the significant prevention of inflammatory bone loss. These results highlight the multifunctionality of Au@MPN-BMP2 nanoparticles as a promising therapeutic approach for periodontitis, addressing both microbial causative factors and an overactivated immune response. We envision that the rational design of metal–phenolic composites will provide versatile nanoplatforms for tissue regeneration and potential clinical applications.
ISSN:1944-8244
1944-8252
1944-8252
DOI:10.1021/acsami.3c19621