The link between obesity and the gut microbiota and immune system in early-life

In early-life, the gut microbiota is highly modifiable, being modulated by external factors such as maternal microbiota, mode of delivery, and feeding strategies. The composition of the child's gut microbiota will deeply impact the development and maturation of its immune system, with consequen...

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Bibliographic Details
Published in:Critical reviews in microbiology 2024-04, p.1-21
Main Authors: Magalhães, Maria Inês, Azevedo, Maria João, Castro, Flávia, Oliveira, Maria José, Costa, Ângela M, Sampaio Maia, Benedita
Format: Article
Language:English
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Summary:In early-life, the gut microbiota is highly modifiable, being modulated by external factors such as maternal microbiota, mode of delivery, and feeding strategies. The composition of the child's gut microbiota will deeply impact the development and maturation of its immune system, with consequences for future health. As one of the main sources of microorganisms to the child, the mother represents a crucial factor in the establishment of early-life microbiota, impacting the infant's wellbeing. Recent studies have proposed that dysbiotic maternal gut microbiota could be transmitted to the offspring, influencing the development of its immunity, and leading to the development of diseases such as obesity. This paper aims to review recent findings in gut microbiota and immune system interaction in early-life, highlighting the benefits of a balanced gut microbiota in the regulation of the immune system.
ISSN:1040-841X
1549-7828
DOI:10.1080/1040841X.2024.2342427