Assessment of Sleep Disorders in Patients with CVID

Inborn errors of immunity have been associated with reduced health-related quality of life and increased fatigue. Sleep disorders, which have been shown to contribute to fatigue and other health concerns, are prevalent in the general population, but there are limited studies evaluating these conditi...

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Bibliographic Details
Published in:Journal of clinical immunology 2024-06, Vol.44 (5), p.109, Article 109
Main Authors: Punj, Mantavya, Neshat, Seyed Sina, Mateus, Alejandra Yu Lee, Cheung, Joseph, Squire, Jacqueline D.
Format: Article
Language:English
Subjects:
Adult
Aged
Apnea
Biomedical and Life Sciences
Biomedicine
Common variable immunodeficiency
Common Variable Immunodeficiency - complications
Common Variable Immunodeficiency - diagnosis
Common Variable Immunodeficiency - epidemiology
Fatigue
Fatigue - diagnosis
Fatigue - epidemiology
Fatigue - etiology
Female
Humans
Immunology
Infectious Diseases
Internal Medicine
Male
Medical Microbiology
Middle Aged
Prevalence
Quality of Life
Severity of Illness Index
Sleep apnea
Sleep Apnea Syndromes - diagnosis
Sleep Apnea Syndromes - epidemiology
Sleep disorders
Sleep Wake Disorders - diagnosis
Sleep Wake Disorders - epidemiology
Sleep Wake Disorders - etiology
Surveys and Questionnaires
Citations: Items that this one cites
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Summary:Inborn errors of immunity have been associated with reduced health-related quality of life and increased fatigue. Sleep disorders, which have been shown to contribute to fatigue and other health concerns, are prevalent in the general population, but there are limited studies evaluating these conditions in patients with common variable immunodeficiency (CVID). Our aim was to evaluate the prevalence of fatigue, sleep disturbances, and sleep-disordered breathing in adults with CVID. Patients completed 4 validated, self-administered questionnaires and a 1-night disposable home sleep apnea test. Our results demonstrated increased median Patient-Reported Outcomes Measurement Information System fatigue scores of 58.7 in patients with CVID in addition to clinically significant fatigue as measured by Fatigue Severity Scale score (median, 5.2) and overall poor sleep quality based on global Pittsburgh Sleep Quality Index score (median, 9.0). For CVID patients who completed the home sleep apnea test, 76.9% met criteria for sleep-disordered breathing with an Apnea-Hypopnea Index score of 5 or greater. The results of our study indicate that patients with CVID may have increased rates of undiagnosed sleep disorders that may contribute to increased fatigue and reduced health-related quality of life.
ISSN:0271-9142
1573-2592
1573-2592
DOI:10.1007/s10875-024-01711-y