Role of intracranial bone marrow mesenchymal stem cells in stroke recovery: A focus on post-stroke inflammation and mitochondrial transfer

• Published in: Brain research 2024-08, Vol.1837, p.148964-148964, Article 148964
• Main Authors: Ming, Jiang, Liao, Yidong, Song, Wenxue, Wang, Zili, Cui, Junshuan, He, Longcai, Chen, Guangtang, Xu, Kaya
• Format: Article
• Language: English
• Subjects: Bone marrow mesenchymal stem cells; Inflammatory response; Ischemic stroke; Mitochondria; Tunneling nanotubes
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2024.148964

[Display omitted] •Bone marrow mesenchymal stem cells protect neurologic function by modulating central and peripheral inflammatory responses after stroke.•Impaired mitochondrial function is strongly associated with neuronal apoptosis.•Bone marrow mesenchymal stem cells can transfer mitochondria with other cells through tunneling nanotubes.•The paracrine function of bone marrow mesenchymal stem cells has therapeutic effects on ischemic stroke. Stem cell therapy has become a hot research topic in the medical field in recent years, with enormous potential for treating a variety of diseases. In particular, bone marrow mesenchymal stem cells (BMSCs) have wide-ranging applications in the treatment of ischemic stroke, autoimmune diseases, tissue repair, and difficult-to-treat diseases. BMSCs can differentiate into multiple cell types and exhibit strong immunomodulatory properties. Although BMSCs can regulate the inflammatory response activated after stroke, the mechanism by which BMSCs regulate inflammation remains unclear and requires further study. Recently, stem cell therapy has emerged as a potentially effective approach for enhancing the recovery process following an ischemic stroke. For example, by regulating post-stroke inflammation and by transferring mitochondria to exert therapeutic effects. Therefore, this article reviews the therapeutic effects of intracranial BMSCs in regulating post-stroke inflammation and mitochondrial transfer in the treatment of stroke, providing a basis for further research.