Strengthening preclinical testing to increase safety in surgical mesh

Inflammatory and fibrotic responses to polypropylene mesh led to the withdrawal of this practice for treatment of stress urinary incontinence and pelvic organ prolapse in women in some countries. Improved material testing has been urged. We report poor responses of polypropylene mesh to repeated mec...

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Bibliographic Details
Published in:Nature reviews. Urology 2024-09, Vol.21 (9), p.515-516
Main Authors: Farr, Nicholas T. H., Workman, Victoria L., Chapple, Christopher R., MacNeil, Sheila, Rodenburg, Cornelia
Format: Article
Language:English
Subjects:
692/308/2778
692/4025
Animals
Biocompatibility
Clinical Outlook
Fourier transforms
Humans
Materials Testing - methods
Medical equipment
Medicine
Medicine & Public Health
Oxidative stress
Pelvic organ prolapse
Pelvis
Surgery
Surgical mesh
Surgical Mesh - adverse effects
Teaching hospitals
Test methods
Urinary incontinence
Urology
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Description
Summary:Inflammatory and fibrotic responses to polypropylene mesh led to the withdrawal of this practice for treatment of stress urinary incontinence and pelvic organ prolapse in women in some countries. Improved material testing has been urged. We report poor responses of polypropylene mesh to repeated mechanical distension and macrophage interrogation. These results from preclinical in vitro testing show the potential of this approach for testing and improving materials before their introduction into the clinic.
ISSN:1759-4812
1759-4820
1759-4820
DOI:10.1038/s41585-024-00889-5