Loading…
Accelerated 3D multi-echo spin-echo sequence with a subspace constrained reconstruction for whole mouse brain T 2 mapping
To accelerate whole-brain quantitative mapping in preclinical imaging setting. A three-dimensional (3D) multi-echo spin echo sequence was highly undersampled with a variable density Poisson distribution to reduce the acquisition time. Advanced iterative reconstruction based on linear subspace constr...
Saved in:
Published in: | Magnetic resonance in medicine 2024-10, Vol.92 (4), p.1525 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | To accelerate whole-brain quantitative
mapping in preclinical imaging setting.
A three-dimensional (3D) multi-echo spin echo sequence was highly undersampled with a variable density Poisson distribution to reduce the acquisition time. Advanced iterative reconstruction based on linear subspace constraints was employed to recover high-quality raw images. Different subspaces, generated using exponential or extended-phase graph (EPG) simulations or from low-resolution calibration images, were compared. The subspace dimension was investigated in terms of
precision. The method was validated on a phantom containing a wide range of
and was then applied to monitor metastasis growth in the mouse brain at 4.7T. Image quality and
estimation were assessed for 3 acceleration factors (6/8/10).
The EPG-based dictionary gave robust estimations of a large range of
. A subspace dimension of 6 was the best compromise between
precision and image quality. Combining the subspace constrained reconstruction with a highly undersampled dataset enabled the acquisition of whole-brain
maps, the detection and the monitoring of metastasis growth of less than 500
.
Subspace-based reconstruction is suitable for 3D
mapping. This method can be used to reach an acceleration factor up to 8, corresponding to an acquisition time of 25 min for an isotropic 3D acquisition of 156
m on the mouse brain, used here for monitoring metastases growth. |
---|---|
ISSN: | 1522-2594 1522-2594 |
DOI: | 10.1002/mrm.30146 |