Sex Disparity in the Association of Metabolic Syndrome with Cognitive Impairment

Metabolic syndrome (MS) is a constellation of several cardiometabolic risk factors. We investigated sex disparity in the associations between MS and cognitive impairment using cross-sectional data from Taiwan Biobank. We determined the associations of MS and its five components with cognitive impair...

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Bibliographic Details
Published in:Journal of clinical medicine 2024-05, Vol.13 (9), p.2571
Main Authors: Chang, Yi-Min, Lee, Chia-Lin, Wang, Jun-Sing
Format: Article
Language:English
Subjects:
Biobanks
Blood cholesterol
Blood pressure
Cholesterol
Cognition & reasoning
Cognition disorders
Cognitive ability
Complications and side effects
Cross-sectional studies
Dementia
Demographic aspects
Development and progression
Diabetes
Diagnosis
Females
Forecasts and trends
Gender differences
High density lipoprotein
Higher education
Hypertension
Males
Medical research
Medicine, Experimental
Metabolic syndrome
Metabolic syndrome X
Regression analysis
Risk factors
Type 2 diabetes
Womens health
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Summary:Metabolic syndrome (MS) is a constellation of several cardiometabolic risk factors. We investigated sex disparity in the associations between MS and cognitive impairment using cross-sectional data from Taiwan Biobank. We determined the associations of MS and its five components with cognitive impairment (mini-mental state examination, MMSE < 24) and the five domains of MMSE using logistic regression analyses. A total of 7399 men and 11,546 women were included, and MS was significantly associated with cognitive impairment only in women (adjusted OR 1.48, 95% CI 1.29-1.71, = 0.001) (p for interaction 0.005). In women, the association with MS was significant in orientation (adjusted OR 1.21, 95% CI 1.07-1.37, = 0.003), memory (adjusted OR 1.12, 95% CI 1.01-1.25, = 0.034) and design copying (adjusted OR 1.41, 95% CI 1.23-1.62, = 0.001) ( value for interaction 0.039, 0.023, and 0.093, respectively). Among the components of MS, a large waist circumference (adjusted OR 1.25, 95% CI 1.08-1.46, = 0.003), high fasting glucose (adjusted OR 1.16, 95% CI 1.00-1.34, = 0.046), and low HDL cholesterol (adjusted OR 1.16, 95% CI 1.00-1.34, = 0.049) were significantly associated with cognitive impairment in women. Our findings suggest that sex has a significant influence on the association between MS and cognitive dysfunction, especially in orientation and memory.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13092571