Associations of plant-based foods, red and processed meat, and dairy with gut microbiome in Finnish adults

• Published in: European journal of nutrition 2024-09, Vol.63 (6), p.2247-2260
• Main Authors: Maukonen, Mirkka, Koponen, Kari K, Havulinna, Aki S, Kaartinen, Niina E, Niiranen, Teemu, Méric, Guillaume, Pajari, Anne-Maria, Knight, Rob, Salomaa, Veikko, Männistö, Satu
• Format: Article
• Language: English
• Subjects: butyrates; Cereals; cheeses; Chemistry; Chemistry and Materials Science; Citrobacter freundii; cream; Dairy products; fermented milk; Fermented milk products; Food composition; Food consumption; Food processing; fruit consumption; Intestinal microflora; intestinal microorganisms; Lactobacillus delbrueckii; Meat; microbial communities; Microbiomes; Milk; Nutrition; Opportunist infection; Original Contribution; Plant-based foods; Population studies; Probiotics; processed meat; red meat; Roseburia hominis; species; species diversity; Vegetables
• ISSN: 1436-6207; 1436-6215; 1436-6215
• DOI: 10.1007/s00394-024-03406-x

Purpose Population-based studies on the associations of plant-based foods, red meat or dairy with gut microbiome are scarce. We examined whether the consumption of plant-based foods (vegetables, potatoes, fruits, cereals), red and processed meat (RPM) or dairy (fermented milk, cheese, other dairy products) are related to gut microbiome in Finnish adults. Methods We utilized data from the National FINRISK/FINDIET 2002 Study ( n  = 1273, aged 25–64 years, 55% women). Diet was assessed with 48-hour dietary recalls. Gut microbiome was analyzed using shallow shotgun sequencing. We applied multivariate analyses with linear models and permutational ANOVAs adjusted for relevant confounders. Results Fruit consumption was positively (beta = 0.03, SE = 0.01, P  = 0.04), while a dairy subgroup including milk, cream and ice-creams was inversely associated (beta=-0.03, SE 0.01, P  = 0.02) with intra-individual gut microbiome diversity (alpha-diversity). Plant-based foods (R 2  = 0.001, P  = 0.03) and dairy (R 2  = 0.002, P  = 0.01) but not RPM (R 2  = 0.001, P  = 0.38) contributed to the compositional differences in gut microbiome (beta-diversity). Plant-based foods were associated with several butyrate producers/cellulolytic species including Roseburia hominis . RPM associations included an inverse association with R. hominis. Dairy was positively associated with several lactic producing/probiotic species including Lactobacillus delbrueckii and potentially opportunistic pathogens including Citrobacter freundii. Dairy, fermented milk, vegetables, and cereals were associated with specific microbial functions. Conclusion Our results suggest a potential association between plant-based foods and dairy or their subgroups with microbial diversity measures. Furthermore, our findings indicated that all the food groups were associated with distinct overall microbial community compositions. Plant-based food consumption particularly was associated with a larger number of putative beneficial species.