Conservation of the Pal/Rim Pathway in Ustilaginomycetes

The ability of fungi to effectively sense and internalize signals related to extracellular changing environments is essential for survival. This adaptability is particularly important for fungal pathogens of humans and plants that must sense and respond to drastic environmental changes when colonizi...

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Bibliographic Details
Published in:Current microbiology 2024-07, Vol.81 (7), p.173, Article 173
Main Authors: Martínez-Soto, Domingo, García-Ortega, Luis F., Guzmán-Rincón, Andrés, Ortiz-Castellanos, Lucila, León-Ramírez, Claudia G.
Format: Article
Language:English
Subjects:
Adaptability
Ascomycota
Ascomycota - genetics
Ascomycota - metabolism
Biomedical and Life Sciences
Biotechnology
Changing environments
Conservation
Conserved sequence
Endosomal Sorting Complexes Required for Transport - genetics
Endosomal Sorting Complexes Required for Transport - metabolism
Environmental changes
Fungal Proteins - genetics
Fungal Proteins - metabolism
Fungi
Hydrogen-Ion Concentration
Life Sciences
Microbiology
Molecular modelling
pH effects
Phylogeny
Protein transport
Proteins
Short Communication
Signal Transduction
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Summary:The ability of fungi to effectively sense and internalize signals related to extracellular changing environments is essential for survival. This adaptability is particularly important for fungal pathogens of humans and plants that must sense and respond to drastic environmental changes when colonizing their hosts. One of the most important physicochemical factors affecting fungal growth and development is the pH. Ascomycota fungal species possess mechanisms such as the Pal/Rim pathway for external pH sensing and adaptation. However, the conservation of this mechanism in other fungi, such as Ustilaginomycetes is still little studied. To overcome this knowledge gap, we used a comparative genomic approach to explore the conservation of the Pal/Rim pathway in the 13 best sequenced and annotated Ustilaginomycetes. Our findings reveal that the Rim proteins and the Endosomal Sorting Complex Required for Transport (ESCRT) proteins are conserved in Ustilaginomycetes. They conserve the canonical domains present in Pal/Rim and ESCRT proteins of Ascomycota. This study sheds light on the molecular mechanisms used by these fungi for responding to extracellular stresses such as the pH, and open the door to further experimentations for understanding the molecular bases of the signaling in Ustilaginomycetes.
ISSN:0343-8651
1432-0991
1432-0991
DOI:10.1007/s00284-024-03696-8