Patterns of Care Following a Positive Fecal Blood Test for Colorectal Cancer: A Mixed Methods Study

• Published in: Journal of general internal medicine : JGIM 2024-12, Vol.39 (16), p.3205-3216
• Main Authors: Hahn, Erin E, Munoz-Plaza, Corrine E, Jensen, Christopher D, Ghai, Nirupa R, Pak, Katherine, Amundsen, Britta I, Contreras, Richard, Cannizzaro, Nancy, Chubak, Jessica, Green, Beverly B, Skinner, Celette Sugg, Halm, Ethan A, Schottinger, Joanne E, Levin, Theodore R
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Blood; Blood tests; Cancer; Cohort Studies; Colonoscopy; Colonoscopy - statistics & numerical data; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - diagnosis; Comorbidity; Early Detection of Cancer - methods; Early Detection of Cancer - statistics & numerical data; Feces; Female; Humans; Male; Middle Aged; Mixed methods research; Occult Blood; Patients; Qualitative analysis
• ISSN: 0884-8734; 1525-1497; 1525-1497
• DOI: 10.1007/s11606-024-08764-0

Multilevel barriers to colonoscopy after a positive fecal blood test for colorectal cancer (CRC) are well-documented. A less-explored barrier to appropriate follow-up is repeat fecal testing after a positive test. We investigated this phenomenon using mixed methods. This sequential mixed methods study included quantitative data from a large cohort of patients 50-89 years from four healthcare systems with a positive fecal test 2010-2018 and qualitative data from interviews with physicians and patients. Logistic regression was used to evaluate whether repeat testing was associated with failure to complete subsequent colonoscopy and to identify factors associated with repeat testing. Interviews were coded and analyzed to explore reasons for repeat testing. A total of 316,443 patients had a positive fecal test. Within 1 year, 76.3% received a colonoscopy without repeat fecal testing, 3% repeated testing and then received a colonoscopy, 4.4% repeated testing without colonoscopy, and 16.3% did nothing. Among repeat testers (7.4% of total cohort, N = 23,312), 59% did not receive a colonoscopy within 1 year. In adjusted models, those with an initial positive test followed by a negative second test were significantly less likely to receive colonoscopy than those with two successive positive tests (OR 0.37, 95% CI 0.35-0.40). Older age (65-75 vs. 50-64 years: OR 1.37, 95% CI 1.33-1.41) and higher comorbidity score (≥ 4 vs. 0: OR 1.75, 95% CI 1.67-1.83) were significantly associated with repeat testing compared to those who received colonoscopy without repeat tests. Qualitative interview data revealed reasons underlying repeat testing, including colonoscopy avoidance, bargaining, and disbelief of positive results. Among patients in this cohort, 7.4% repeated fecal testing after an initial positive test. Of those, over half did not go on to receive a colonoscopy within 1 year. Efforts to improve CRC screening must address repeat fecal testing after a positive test as a barrier to completing colonoscopy.