Is vitamin D receptor (VDR) polymorphism associated with head and neck cancer risk? A systematic review and meta‐analysis

Background Head and neck cancer encompasses neoplasms affecting the oral cavity, pharynx, larynx, and thyroid. Identifying factors that modulate the carcinogenesis process can aid in identifying subgroups at higher risk of developing the disease, enabling implementation of prevention programs. Vitam...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2024-07, Vol.53 (6), p.341-357
Main Authors: Ferri, Camila Alves, Lima, Vanessa Justo, Santos, Patrícia Koehler, Rados, Pantelis Varvaki, Visioli, Fernanda
Format: Article
Language:English
Subjects:
Carcinogenesis
CDX2 protein
Gene frequency
genetic polymorphism
Genotyping
Head & neck cancer
Head and neck
head and neck neoplasms
Larynx
Meta-analysis
Oral carcinoma
Oral cavity
Pharynx
Polymorphism
Reviews
Systematic review
Thyroid cancer
Vitamin D
vitamin D receptor
Vitamin D receptors
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Summary:Background Head and neck cancer encompasses neoplasms affecting the oral cavity, pharynx, larynx, and thyroid. Identifying factors that modulate the carcinogenesis process can aid in identifying subgroups at higher risk of developing the disease, enabling implementation of prevention programs. Vitamin D receptor polymorphisms can affect the carcinogenesis of various tumors by altering vitamin D metabolism and cellular response. Methods To elucidate the role of vitamin D receptor polymorphisms in head and neck cancer, a systematic review was performed, searching the Embase, PubMed, Scopus, and Lilacs databases. A total of 19 articles met the inclusion criteria. The frequency of vitamin D receptors polymorphism alleles (FokI, ApaI, BsmI, TaqI, Cdx2, rs2107301, rs2238135) was recorded and pooled to calculate the odds ratio in a meta‐analysis using the Review Manager software. Results Subgroup analysis demonstrated significant associations in the anatomical site of cancer (oral cancer in ApaI and BsmI, and unspecified subsites of head and neck cancer in TaqI), genotyping method (FokI and BsmI), and continent of the study (ApaI, FokI, and BsmI). Conclusion Our findings were heterogeneous, as with other evidence available in the literature. Therefore, more clinical studies with larger sample sizes are needed to obtain more accurate results on the relationship between vitamin D receptor polymorphism and head and neck cancer.
ISSN:0904-2512
1600-0714
1600-0714
DOI:10.1111/jop.13543