Parkinson's disease is associated with low striated esophagus contractility potentially contributing to the development of dysphagia

Background Parkinson's disease (PD) is the second most common neurodegenerative disorder, and more than 80% of PD patients will develop oropharyngeal dysphagia. Despite its striated histology, proximity to airway, and potential negative impact of its dysfunction on bolus transport and airway sa...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2024-08, Vol.36 (8), p.e14822-n/a
Main Authors: Kerschner, Alexander, Hassan, Hamza, Kern, Mark, Edeani, Francis, Mei, Ling, Sanvanson, Patrick, Shaker, Reza, Yu, Elliot
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Classification
Contractility
Deglutition Disorders - diagnosis
Deglutition Disorders - etiology
Deglutition Disorders - physiopathology
Dysphagia
Esophageal Motility Disorders - diagnosis
Esophageal Motility Disorders - physiopathology
Esophagus
Esophagus - physiopathology
Female
high‐resolution manometry
Humans
Male
Manometry
Middle Aged
Movement disorders
Muscle Contraction - physiology
Neurodegenerative diseases
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson's disease
Respiratory tract
striated esophagus
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Summary:Background Parkinson's disease (PD) is the second most common neurodegenerative disorder, and more than 80% of PD patients will develop oropharyngeal dysphagia. Despite its striated histology, proximity to airway, and potential negative impact of its dysfunction on bolus transport and airway safety, the contractile function of the striated esophagus in PD patients has not been systematically studied. Methods Using our repository of clinical manometry and the Milwaukee ManoBank, we analyzed high‐resolution manometry (HRM) studies of 20 PD patients, mean age 69.1 (range 38–87 years); 30 non‐PD patients with dysphagia, mean age 64.0 (44–86 years); and 32 healthy volunteers, mean age 65.3 (39–86 years). Patients with abnormal findings based on Chicago Classification 4.0 were identified. Repeat analysis was performed in 20% of the manometric tracings by a different investigator with inter‐rater concordance between 0.91 and 0.99. Key Results The striated esophageal contractile integral in PD patients was significantly lower than that in non‐PD dysphagic patients and healthy controls (p = 0.03 and
ISSN:1350-1925
1365-2982
1365-2982
DOI:10.1111/nmo.14822