Recent Advances in DNA Nanotechnology‐Based Sensing Platforms for Rapid Virus Detection

• Published in: Chembiochem : a European journal of chemical biology 2024-09, Vol.25 (17), p.e202400230-n/a
• Main Authors: Dong, Yuxiang, Guo, Cheng, Wang, Jialing, Ye, Changqing, Min, Qianhao
• Format: Article
• Language: English
• Subjects: COVID-19; Deoxyribonucleic acid; DNA; DNA nanotechnology; DNA viruses; enzyme signal amplification; multivalent recognition; Nanotechnology; Pandemics; Platforms; Public health; rapid virus detection; Viruses
• ISSN: 1439-4227; 1439-7633; 1439-7633
• DOI: 10.1002/cbic.202400230

Several major viral pandemics in history have significantly impacted the public health of human beings. The COVID‐19 pandemic has further underscored the critical need for early detection and screening of infected individuals. However, current detection techniques are confronted with deficiencies in sensitivity and accuracy, restricting the capability of detecting trace amounts of viruses in human bodies and in the environments. The advent of DNA nanotechnology has opened up a feasible solution for rapid and sensitive virus determination. By harnessing the designability and addressability of DNA nanostructures, a range of rapid virus sensing platforms have been proposed. This review overviewed the recent progress, application, and prospect of DNA nanotechnology‐based rapid virus detection platforms. Furthermore, the challenges and developmental prospects in this field were discussed. Rapid screening of infected individuals plays an essential role in viral pandemics. This review highlights the recent progress, application, and prospect of DNA nanotechnology‐based virus detection platforms, with the goal of offering insights and inspiration for the development of innovative virus detection methods to deal with potential large‐scale outbreaks of infectious diseases in the future.