Linking phosphoinositide function to mitosis

Phosphoinositides (PtdIns) are a family of differentially phosphorylated lipid second messengers localized to the cytoplasmic leaflet of both plasma and intracellular membranes. Kinases and phosphatases can selectively modify the PtdIns composition of different cellular compartments, leading to the...

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Bibliographic Details
Published in:Cell reports (Cambridge) 2024-06, Vol.43 (6), p.114273, Article 114273
Main Authors: Prever, Lorenzo, Squillero, Gabriele, Hirsch, Emilio, Gulluni, Federico
Format: Article
Language:English
Subjects:
Animals
Cytokinesis - physiology
Humans
Mitosis
Phosphatidylinositols - metabolism
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Summary:Phosphoinositides (PtdIns) are a family of differentially phosphorylated lipid second messengers localized to the cytoplasmic leaflet of both plasma and intracellular membranes. Kinases and phosphatases can selectively modify the PtdIns composition of different cellular compartments, leading to the recruitment of specific binding proteins, which control cellular homeostasis and proliferation. Thus, while PtdIns affect cell growth and survival during interphase, they are also emerging as key drivers in multiple temporally defined membrane remodeling events of mitosis, like cell rounding, spindle orientation, cytokinesis, and abscission. In this review, we summarize and discuss what is known about PtdIns function during mitosis and how alterations in the production and removal of PtdIns can interfere with proper cell division. Prever et al. examine phosphoinositides (PtdIns) in cell division, elucidating their roles in membrane trafficking and remodeling. The review underscores how PtdIns production and interconversion regulate daughter cell separation and how perturbations in these processes disrupt cell division.
ISSN:2211-1247
2211-1247
DOI:10.1016/j.celrep.2024.114273