Treatment strategies and responses for attacks of neuromyelitis optica spectrum disorder: A real-world retrospective cohort study

• Published in: Journal of the neurological sciences 2024-07, Vol.462, p.123099-123099, Article 123099
• Main Authors: Contentti, Edgar Carnero, Lopez, Pablo A, Pettinicchi, Juan Pablo, Miguez, Jimena, Patrucco, Liliana, Cristiano, Edgardo, Liwacki, Susana, Tkachuk, Verónica, Balbuena, María E, Vrech, Carlos, Deri, Norma, Correale, Jorge, Marrodan, Mariano, Ysrraelit, María C, Leguizamon, Felisa, Luetic, Geraldine, Tavolini, Darío, Mainella, Carolina, Zanga, Gisela, Burgos, Marcos, Hryb, Javier, Barboza, Andrés, Lazaro, Luciana, Alonso, Ricardo, Liguori, Nora Fernández, Nadur, Débora, Serena, Marina Alonso, Caride, Alejandro, Rojas, Juan I
• Format: Article
• Language: English
• Subjects: Neurology; NMOSD; Prognosis; Relapses; Response; Treatment
• ISSN: 0022-510X; 1878-5883; 1878-5883
• DOI: 10.1016/j.jns.2024.123099

AbstractWe aimed to assess the treatment strategies utilized in patients with neuromyelitis optica spectrum disorder (NMOSD) experiencing relapses, including their frequency, types, and response after 6 months based on the Expanded Disability Status Scale (EDSS) score. MethodsWe conducted a retrospective study involving NMOSD patients from the Argentinean MS and NMOSD registry (RelevarEM, NCT 03375177). Treatment response at 6 months was categorized as “good” if the EDSS score decreased by ≥1 point after a nadir EDSS score ≤ 3, or by ≥2 points after a nadir EDSS score > 3, “poor” if the EDSS score decrease was slighter, and as “absent” if the EDSS score remained unchanged or worsened. ResultsWe included 120 NMOSD patients (seropositive N = 75), who experienced 250 NMOSD-related relapses and received 248 treatments. At 6 months, complete recovery was achieved in 70/98 (71.4%) and 15/19 (79%) patients, respectively. Predictors of a “good” response in our regression model were a younger age at disease onset (OR:3.54, CI95% 2.45–5.01, p