MRI for hepatocellular carcinoma and the role of abbreviated MRI for surveillance of hepatocellular carcinoma

Introduction Hepatocellular carcinoma (HCC) constitutes the majority of liver cancers and significantly impacts global cancer mortality. While ultrasound (US) with or without alpha‐fetoprotein is the mainstay for HCC surveillance, its limitations highlight the necessity for more effective surveillan...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2024-10, Vol.39 (10), p.1969-1981
Main Authors: Maung, Soe Thiha, Tanpowpong, Natthaporn, Satja, Minchanat, Treeprasertsuk, Sombat, Chaiteerakij, Roongruedee
Format: Article
Language:English
Subjects:
abbreviated MRI
Carcinoma, Hepatocellular - diagnostic imaging
Clinical trials
Comparative analysis
Contrast Media - administration & dosage
Cost-Benefit Analysis
Hepatocellular carcinoma
Humans
Liver cancer
Liver Neoplasms - diagnostic imaging
Magnetic resonance imaging
Magnetic Resonance Imaging - economics
Magnetic Resonance Imaging - methods
Meta-analysis
MRI
non‐contrast
screening
Surveillance
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Summary:Introduction Hepatocellular carcinoma (HCC) constitutes the majority of liver cancers and significantly impacts global cancer mortality. While ultrasound (US) with or without alpha‐fetoprotein is the mainstay for HCC surveillance, its limitations highlight the necessity for more effective surveillance tools. Therefore, this review explores evolving imaging modalities and abbreviated magnetic resonance imaging (MRI) (AMRI) protocols as promising alternatives, addressing challenges in HCC surveillance. Areas Covered This comprehensive review delves into the evaluation and challenges of HCC surveillance tools, focusing on non‐contrast abbreviated MRI (NC‐AMRI) and contrast‐enhanced abbreviated MRI protocols. It covers the implementation of AMRI for HCC surveillance, patient preferences, adherence, and strategies for optimizing cost‐effectiveness. Additionally, the article provides insights into prospects for HCC surveillance by summarizing meta‐analyses, prospective studies, and ongoing clinical trials evaluating AMRI protocols. Expert Opinion The opinions underscore the transformative impact of AMRI on HCC surveillance, especially in overcoming US limitations. Promising results from NC‐AMRI protocols indicate its potential for high‐risk patient surveillance, though prospective studies in true surveillance settings are essential for validation. Future research should prioritize risk‐stratified AMRI protocols and address cost‐effectiveness for broader clinical implementation, alongside comparative analyses with US for optimal surveillance strategies.
ISSN:0815-9319
1440-1746
1440-1746
DOI:10.1111/jgh.16643