Prevalence of PICC-related thrombosis in patients with hematological malignancies: a systematic review

Purpose To estimate the prevalence of peripherally inserted central catheter (PICC)-related venous thrombosis in patients with hematological malignancies. Methods A systematic review of observational studies that evaluated the occurrence of PICC-related venous thrombosis in children, adults, and old...

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Bibliographic Details
Published in:Supportive care in cancer 2024-07, Vol.32 (7), p.462, Article 462
Main Authors: dos Santos, Bruna Nogueira, Beato, Beatriz Volpin Gomes, Ferreira, Elaine Barros, Braga, Fernanda Titareli Merizio Martins, dos Reis, Paula Elaine Diniz, Silveira, Renata Cristina de Campos Pereira
Format: Article
Language:English
Subjects:
Adult
Blood cancer
Catheterization, Central Venous - adverse effects
Catheterization, Peripheral - adverse effects
Catheters
Child
Health risks
Hematologic Neoplasms - complications
Hematology
Humans
Medicine
Medicine & Public Health
Nursing
Nursing Research
Oncology
Pain Medicine
Prevalence
Rehabilitation Medicine
Review
Systematic review
Thrombosis
Venous Thrombosis - epidemiology
Venous Thrombosis - etiology
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Summary:Purpose To estimate the prevalence of peripherally inserted central catheter (PICC)-related venous thrombosis in patients with hematological malignancies. Methods A systematic review of observational studies that evaluated the occurrence of PICC-related venous thrombosis in children, adults, and older people with hematological malignancies was conducted. Searches were carried out on June 12th, 2023 on PubMed, CINAHL, Embase, Web of Science Core Collection, Scopus, and LILACS, and to gray literature on Google Scholar, and ProQuest Dissertations and Theses Global. Eligibility criteria were applied independently by two reviewers, first on the titles and abstracts on the Rayyan platform and then on the full text of eligible studies. Risk of bias was assessed by the JBI checklist. Data were summarized descriptively, and the meta-analysis was carried out using the MetaXL 5.3 software. The review followed JBI guidelines and PRISMA for reporting. Results In the 40 studies included, prevalence of PICC-related venous thrombosis was 9% in general, 9% in adults, and 6% in children with hematological malignancies. Most studies only evaluated cases of symptomatic thrombosis ( n = 25; 64%). Conclusion Patients with hematological malignancies using PICC have an estimated prevalence of PICC-related venous thrombosis of 9%, and this rate may be underestimated due to the consideration of mostly symptomatic cases.
ISSN:0941-4355
1433-7339
1433-7339
DOI:10.1007/s00520-024-08636-7