A Case of Secondary Growth Hormone Deficiency that Developed into Cirrhosis after Several Years of Interrupted Growth Hormone Replacement Therapy

This case report describes a patient who received hormone replacement therapy for secondary panhypopituitarism and subsequently developed diabetes. His physician decided to discontinue growth hormone (GH) replacement, which was previously deemed contraindicated. Following the diagnosis of fatty live...

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Bibliographic Details
Published in:Internal Medicine 2024, pp.3896-24
Main Authors: Sueki, Ayana, Kaya, Daisuke, Nagamatsu, Shinsaku, Yamamoto, Chisa, Ohta, Kohei, Matsuo, Yuya, Nishio, Yuya, Komeda, Yusuke, Kikukawa, Shoma, Matsuura, Kyohei, Matsuo, Hideki, Uejima, Masakazu, Moriya, Kei
Format: Article
Language:English
Subjects:
diabetes mellitus
growth hormone
liver cirrhosis
nonalcoholic steatohepatitis
replacement therapy
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Summary:This case report describes a patient who received hormone replacement therapy for secondary panhypopituitarism and subsequently developed diabetes. His physician decided to discontinue growth hormone (GH) replacement, which was previously deemed contraindicated. Following the diagnosis of fatty liver, the patient began to exhibit liver damage that progressed over the ensuing years, ultimately leading to cirrhosis. Common factors linked to cirrhosis were excluded, leading to the belief that GH deficiency over several years was the primary contributor to cirrhosis. Therefore, when treating patients with GH insufficiency and diabetes, clinicians should carefully consider the potential implications of GH replacement therapy.
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.3896-24