Sleep restriction reduces voluntary isometric quadriceps strength through reduced neuromuscular efficiency, not impaired contractile performance

• Published in: European journal of applied physiology 2024-11, Vol.124 (11), p.3351-3363
• Main Authors: Sigrist, S., Abel, M. G., Best, S. A., Bollinger, L. M.
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Contractility; Human Physiology; Isometric; Knee; Males; Occupational Medicine/Industrial Medicine; Original Article; Quadriceps muscle; Sleep; Sleep deprivation; Sports Medicine
• ISSN: 1439-6319; 1439-6327; 1439-6327
• DOI: 10.1007/s00421-024-05535-x

Acute sleep restriction (SR) reduces strength through an unknown mechanism. Purpose: To determine how SR affects quadriceps contractile function and recruitment. Methods: Eighteen healthy subjects (9 M, 9F, age 23.8 ± 2.8y) underwent isometric (maximal and submaximal), isokinetic (300–60°·s −1 ), and interpolated twitch (ITT) assessment of knee extensors following 3d of adequate sleep (SA; 7–9 h·night −1 ), 3d of SR (5 h·night −1 ), and 7d of washout (WO; 7-9 h·night −1 ). Results: Compared to SA (227.9 ± 76.6Nm) and WO (228.19 ± 62.9Nm), MVIC was lesser following SR (209.9 ± 73.9Nm; p = 0.006) and this effect was greater for males (− 9.8 v. − 4.8%). There was no significant effect of sleep or sleep x speed interaction on peak isokinetic torque. Peak twitch torque was greater in the potentiated state, but no significant effect of sleep was noted. Males displayed greater potentiation of peak twitch torque (12 v. 7.5%) and rate of torque development (16.7 v. 8.2%) than females but this was not affected by sleep condition. ITT-assessed voluntary activation did not vary among sleep conditions (SA: 81.8 ± 13.1% v. SR: 84.4 ± 12.6% v. WO 84.9 ± 12.6%; p = 0.093). SR induced a leftward shift in Torque-EMG relationship at high torque output in both sexes. Compared to SA, females displayed greater y-intercept and lesser slope with SR and WO and males displayed lesser y-intercept and greater slope with SR and WO. Conclusions: Three nights of SR decreases voluntary isometric knee extensor strength, but not twitch contractile properties. Sex-specific differences in neuromuscular efficiency may explain the greater MVIC reduction in males following SR.