Synthetic Angiotensin II ameliorates alterations of systemic hemodynamics, microcirculatory deterioration, and renal damage in septic rats

• Published in: Microvascular research 2024-09, Vol.155, p.104709, Article 104709
• Main Authors: Ergin, Bulent, Kapucu, Aysegul, Chawla, Lakhmir, Ince, Can
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - drug therapy; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Acute Kidney Injury - physiopathology; AKI; Angiotensin 2; Angiotensin II; Animals; Disease Models, Animal; Hemodynamics - drug effects; Inflammation; Kidney - blood supply; Kidney - drug effects; Kidney - physiopathology; Male; Microcirculation; Microcirculation - drug effects; Norepinephrine; Rats; Rats, Wistar; Sepsis; Sepsis - drug therapy; Sepsis - physiopathology
• ISSN: 0026-2862; 1095-9319; 1095-9319
• DOI: 10.1016/j.mvr.2024.104709

Septic shock is a systemic infection that causes persistent systemic hypotension, inflammation, tissue hypoperfusion and acute kidney injury (AKI). Despite norepinephrine being the currently recommended vasopressor agent, an alternative vasopressor agent that positively affects peripheral and organ microcirculatory perfusion and oxygenation is needed. This study investigated a new synthetic Angiotensin II agent suitable for improving microcirculatory parameters in a rat model of sepsis-induced systemic hemodynamic dysfunction. 48 mechanically ventilated, anesthetized male rats were allocated as control; lipopolysaccharide (LPS, 20 mg/kg) and LPS groups received either ringer acetate (RA), norepinephrine (NE), Angiotensin II (Ang II), or a combination of NE and Ang II. Systemic hemodynamics, renal cortical pO2 and perfusion, and muscle microcirculatory oxygen saturation were evaluated. MAP was restored in all LPS groups that received Ang II, NE, and NE + Ang II compared to the LPS group alone (p