The association of prolactin and gonadal hormones with cognition and symptoms in men with schizophrenia spectrum disorder: Divergent effects of testosterone and estrogen

Certain antipsychotics elevate prolactin levels in patients with schizophrenia spectrum disorders (SSD), potentially affecting cognition, symptoms, and hormone levels. This study examines the association between prolactin, testosterone, and estrogen and cognition and symptoms in men with SSD, consid...

Full description

Saved in:
Bibliographic Details
Published in:Schizophrenia research 2024-08, Vol.270, p.273-280
Main Authors: Hamers, Iris M.H., Brand, Bodyl A., Begemann, Marieke J.H., Weickert, Cynthia S., Weickert, Thomas W., Sommer, Iris E.C.
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - pharmacology
Antipsychotics
Cognition - drug effects
Cognition - physiology
Cross-Sectional Studies
Estrogen
Estrogens - blood
Estrogens - pharmacology
Humans
Male
Memory, Short-Term - drug effects
Memory, Short-Term - physiology
Middle Aged
Neuropsychological Tests
Prolactin
Prolactin - blood
Psychiatric Status Rating Scales
Psychotic Disorders - blood
Psychotic Disorders - drug therapy
Psychotic Disorders - physiopathology
Schizophrenia
Schizophrenia - blood
Schizophrenia - complications
Schizophrenia - drug therapy
Schizophrenia - physiopathology
Schizophrenic Psychology
Testosterone
Testosterone - blood
Young Adult
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Certain antipsychotics elevate prolactin levels in patients with schizophrenia spectrum disorders (SSD), potentially affecting cognition, symptoms, and hormone levels. This study examines the association between prolactin, testosterone, and estrogen and cognition and symptoms in men with SSD, considering antipsychotic medication. This cross-sectional study included 128 men with SSD and 44 healthy men from two trials. Patients were divided into a prolactin-sparing (n = 53) and prolactin-raising group (n = 75) based on antipsychotic medication. We examined the association between hormones (testosterone, estrogen and prolactin), and cognition and symptoms using backward linear regression. Three domains of cognition were assessed including: processing speed, verbal fluency, and working memory, while symptoms were measured using the Positive and Negative Syndrome Scale (PANSS). Prolactin levels were highest in the prolactin-raising group, followed by the control group, and lowest in the prolactin-sparing group (H = 45.279, p 
ISSN:0920-9964
1573-2509
1573-2509
DOI:10.1016/j.schres.2024.06.022