Extraocular muscle volume on time‐of‐flight magnetic resonance angiography in patients with myasthenia gravis

Introduction/Aims Despite being a prominent feature of myasthenia gravis (MG), extraocular muscle (EOM) has received little attention in clinical research. The aim of this study was to examine EOM volume in patients with MG and controls using time‐of‐flight magnetic resonance angiography (TOF‐MRA)....

Full description

Saved in:
Bibliographic Details
Published in:Muscle & nerve 2024-09, Vol.70 (3), p.379-386
Main Authors: Chen, Pei, Zhou, Qin, Zhao, Xiaoxiao, Chen, Yingqian, Lin, Zhongqiang, Wang, Mengzhu, Yang, Zhiyun, Liu, Weibin
Format: Article
Language:English
Subjects:
Angiography
Atrophy
Disease control
extraocular muscle
Eye diseases
Flight
Magnetic resonance
magnetic resonance angiography
Medical imaging
Muscles
Myasthenia gravis
Neuromuscular junctions
ophthalmoparesis
Predictive control
Regression analysis
Subgroups
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction/Aims Despite being a prominent feature of myasthenia gravis (MG), extraocular muscle (EOM) has received little attention in clinical research. The aim of this study was to examine EOM volume in patients with MG and controls using time‐of‐flight magnetic resonance angiography (TOF‐MRA). Methods EOM volumes (overall and individual rectus muscles) were calculated using TOF‐MRA images and compared between MG patients (including subgroups) and controls. The correlation between EOM volume and disease duration was examined. Predictive equations for the selected parameters were developed using multiple linear regression analysis. Results EOM volume was lower in MG patients than controls, especially in MG patients with ophthalmoparesis (MG‐O). MG‐O exhibited a moderate negative correlation between EOM volume and disease duration. Multiple linear regression showed that disease duration and EOM status (ophthalmoparesis or not) account for 48.4% of EOM volume. Discussion Patients with MG show atrophy of the EOMs, especially those with ophthalmoparesis and long disease duration.
ISSN:0148-639X
1097-4598
1097-4598
DOI:10.1002/mus.28192