Evidence for direct CO2 ‐mediated alterations in cerebral oxidative metabolism in humans

Aim How the cerebral metabolic rates of oxygen and glucose utilization (CMRO2 and CMRGlc, respectively) are affected by alterations in arterial PCO2 (PaCO2) is equivocal and therefore was the primary question of this study. Methods This retrospective analysis involved pooled data from four separate...

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Published in:Acta Physiologica 2024-09, Vol.240 (9), p.e14197-n/a
Main Authors: Caldwell, Hannah G., Hoiland, Ryan L., Bain, Anthony R., Howe, Connor A., Carr, Jay M. J. R., Gibbons, Travis D., Durrer, Cody G., Tymko, Michael M., Stacey, Benjamin S., Bailey, Damian M., Sekhon, Mypinder S., MacLeod, David B., Ainslie, Philip N.
Format: Article
Language:English
Subjects:
Blood flow
Carbon dioxide
Carotid artery
Cerebral blood flow
cerebral metabolic rate of oxygen
Energy metabolism
Fick principle
Glucose
Glucose metabolism
Hypercapnia
Metabolic rate
Metabolism
Oxidative metabolism
ultrasound
Vertebrae
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Summary:Aim How the cerebral metabolic rates of oxygen and glucose utilization (CMRO2 and CMRGlc, respectively) are affected by alterations in arterial PCO2 (PaCO2) is equivocal and therefore was the primary question of this study. Methods This retrospective analysis involved pooled data from four separate studies, involving 41 healthy adults (35 males/6 females). Participants completed stepwise steady‐state alterations in PaCO2 ranging between 30 and 60 mmHg. The CMRO2 and CMRGlc were assessed via the Fick approach (CBF × arterial‐internal jugular venous difference of oxygen or glucose content, respectively) utilizing duplex ultrasound of the internal carotid artery and vertebral artery to calculate cerebral blood flow (CBF). Results The CMRO2 was altered by 0.5 mL × min−1 (95% CI: −0.6 to −0.3) per mmHg change in PaCO2 (p 
ISSN:1748-1708
1748-1716
1748-1716
DOI:10.1111/apha.14197