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Association between genital gender-affirming surgery and psychiatric comorbidities in individuals with gender incongruence

Previous studies present mixed evidence on the relationship between psychiatric comorbidities and genital gender-affirming surgery (GGAS) in individuals with gender incongruence (GI). This research aims to investigate the psychiatric comorbidity rates post-GGAS in the GI population-namely, depressiv...

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Bibliographic Details
Published in:Journal of sexual medicine 2024-08, Vol.21 (8), p.729-733
Main Authors: Garoosi, Kassra, Yoon, YooJin, Hale, Elijah, Kahan, Riley, Kalia, Nargis, Higuchi, Ty, Mathes, David, Hudish, Tyler, Kaoutzanis, Christodoulos
Format: Article
Language:English
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Summary:Previous studies present mixed evidence on the relationship between psychiatric comorbidities and genital gender-affirming surgery (GGAS) in individuals with gender incongruence (GI). This research aims to investigate the psychiatric comorbidity rates post-GGAS in the GI population-namely, depressive disorders, anxiety disorders, posttraumatic stress disorders, substance abuse disorder, and suicidality. Based on the TriNetX health care database, an international database with >250 million patients, a cross-sectional study was executed comparing psychiatric comorbidity rates among cases of GI with and without GGAS. Individuals were matched for demographic and health-related variables, which included history of cardiovascular disease, diabetes, and obesity. The main focus was to establish the rates and changes in psychiatric comorbidities following GGAS. Among individuals with GI, the study identified 4061 with GGAS and 100 097 without. At 1 year post-GGAS, there was a significant decrease in depression (odds ratio [OR], 0.748; 95% CI, 0.672-0.833; P 
ISSN:1743-6095
1743-6109
1743-6109
DOI:10.1093/jsxmed/qdae077