Maintenance therapy for CTCL: importance for prevention of disease progression

There are no established maintenance protocols for cutaneous lymphomas. We aim to determine patient treatments and outcomes during the COVID-19 pandemic in order to uncover the most effective maintenance protocols for cutaneous lymphomas and impact of treatment interruption. Data was collected retro...

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Bibliographic Details
Published in:Leukemia & lymphoma 2024-12, Vol.65 (12), p.1883-1890
Main Authors: Gordon, Emily R, Trager, Megan H, Kwinta, Bradley D, Stonesifer, Connor J, Lee, Kaitlyn J, Adeuyan, Oluwaseyi, Lapolla, Brigit A, Akilov, Oleg E, Enz, Paula A, Guenova, Emmanuella, Ortiz-Romero, Pablo L, Papadavid, Evangelia, Quaglino, Pietro, Rozati, Sima, Scarisbrick, Julia J, Litman, Thomas, Geskin, Larisa J
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Communicable Disease Control
COVID-19 - epidemiology
COVID-19 - prevention & control
Disease Progression
Female
Humans
Lymphoma, T-Cell, Cutaneous - pathology
Lymphoma, T-Cell, Cutaneous - therapy
Maintenance Chemotherapy - methods
Male
Mechlorethamine - administration & dosage
Mechlorethamine - therapeutic use
Middle Aged
Neoplasm Staging
Phototherapy - methods
Retrospective Studies
SARS-CoV-2
Skin Neoplasms - pathology
Skin Neoplasms - prevention & control
Skin Neoplasms - therapy
Treatment Outcome
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Summary:There are no established maintenance protocols for cutaneous lymphomas. We aim to determine patient treatments and outcomes during the COVID-19 pandemic in order to uncover the most effective maintenance protocols for cutaneous lymphomas and impact of treatment interruption. Data was collected retrospectively from nine international institutions, including 149 patients. Younger patients had earlier stages of disease and were most frequently treated with skin-directed therapies including topical steroids, mechlorethamine gel, and phototherapy. Treatment interruption varied by treatment type and stage, with patients on topical therapies and earlier stages of disease being least likely to experience interruption. Treatment interruption was significantly associated with progression of disease and worse outcomes, with twice as many patients progressing who had interruption compared to those without interruption. This study may demonstrate the significance of continuous maintenance therapies, even in younger patients with early stages of disease.
ISSN:1042-8194
1029-2403
1029-2403
DOI:10.1080/10428194.2024.2376164