The effect of protein administration during critical illness depends on body composition: A secondary analysis of a prospective, observational study

The most adequate amount of protein that should be administered to critically ill patients is still debated and diverging findings are recently accumulating. We hypothesized that the effect of protein administration might depend on the amount of muscle mass. A secondary analysis of a single-centre p...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2024-09, Vol.43 (9), p.1993-1996
Main Authors: Umbrello, Michele, Sterchele, Elda Diletta, Cioata, Ada Cosmina, Mistraletti, Giovanni, Formenti, Paolo
Format: Article
Language:English
Subjects:
Bioimpedance analysis
Body composition
Critically ill
Muscle mass
Muscle ultrasound
Protein administration
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Summary:The most adequate amount of protein that should be administered to critically ill patients is still debated and diverging findings are recently accumulating. We hypothesized that the effect of protein administration might depend on the amount of muscle mass. A secondary analysis of a single-centre prospective observational study of body composition in critically ill patients. Mechanically-ventilated subjects with an expected intensive care unit (ICU) stay >72 h were enrolled. Within 24 h from ICU admission, bioimpedance-derived muscle mass (BIA MM) and rectus femoris cross-sectional area (RF CSA) were measured. The amount of proteins and calories administered on the 7th ICU day was recorded. We enrolled 94 subjects (65 males, actual body weight 72.9 ± 14.4 Kg, BMI 26.0 ± 4.8 kg/m2). Actual body weight was only weakly related to BIA MM (R = 0.478, p 
ISSN:0261-5614
1532-1983
1532-1983
DOI:10.1016/j.clnu.2024.07.018