De novo depression following temporal lobe epilepsy surgery

• Published in: Seizure (London, England) England), 2024-10, Vol.121, p.23-29
• Main Authors: Sala-Padro, Jacint, De la Cruz-Puebla, Myriam, Miró, Júlia, Cucurell, David, López-Barroso, Diana, Vilà-Balló, Adrià, Plans, Gerard, Santurino, Mila, Falip, Mercè, Rodriguez-Fornells, Antoni, Camara, Estela
• Format: Article
• Language: English
• Subjects: Depression; Epilepsy surgery; Functional connectivity; Single-subject
• ISSN: 1059-1311; 1532-2688; 1532-2688
• DOI: 10.1016/j.seizure.2024.06.018

•Temporal lobe epilepsy and mood disorders share a common pathogenic network.•Surgery for Temporal lobe epilepsy may lead to the appearance of mood disorders.•We investigated the connectivity between the Nucleus Accumbens and Hippocampus.•Patients who developed de novo mood disorders had a decrease in connectivity.•A single-subject level analysis was used to account for individual differences. Surgical removal of the mesial temporal lobe can effectively treat drug-resistant epilepsy but may lead to mood disorders. This fact is of particular interest in patients without a prior psychiatric history. The study investigates the relationship between Temporal Lobe Epilepsy (TLE), mood disorders, and the functional connectivity of the Hippocampus (Hipp) and Nucleus Accumbens (NAcc). In this case control study, twenty-seven TLE patients and 18 control subjects participated, undergoing structural and functional magnetic resonance imaging (MRI) scans before and after surgery. Post-surgery, patients were categorized into those developing de novo depression (DnD) within the first year and those without depression (nD). Functional connectivity maps between NAcc and the whole brain were generated, and connectivity strength between the to-be-resected Hipp area and NAcc was compared. Within the first year post-surgery, 7 out of 27 patients developed DnD. Most patients (88.8 %) exhibited a significant reduction in NAcc-Hipp connectivity compared to controls. The DnD group showed notably lower connectivity values than the nD group, with statistically significant disparities. Receiver Operating Characteristic (ROC) curve analysis identified a potential biomarker threshold (Crawford-T value of -2.08) with a sensitivity of 0.83 and specificity of 0.76. The results suggest that functional connectivity patterns within the reward network could serve as a potential biomarker for predicting de novo mood disorders in TLE patients undergoing surgery. This insight may assist in identifying individuals at a higher risk of developing DnD after surgery, enhancing therapeutic guidance and clinical decision-making.