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Explore the Role of Frailty as a Contributor to the Association Between AT(N) Profiles and Cognition in Alzheimer’s Disease

Background: The relationship between Alzheimer’s disease (AD)-related pathology and cognition was not exactly consistent. Objective: To explore whether the association between AD pathology and cognition can be moderated by frailty. Methods: We included 1711 participants from the Alzheimer’s Disease...

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Bibliographic Details
Published in:Journal of Alzheimer's disease 2024-01, Vol.100 (4), p.1333-1343
Main Authors: Han, Bao-Lin, Ma, Ling-Zhi, Han, Shuang-Ling, Mi, Yin-Chu, Liu, Jia-Yao, Sheng, Ze-Hu, Wang, Hui-Fu, Tan, Lan
Format: Article
Language:English
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Summary:Background: The relationship between Alzheimer’s disease (AD)-related pathology and cognition was not exactly consistent. Objective: To explore whether the association between AD pathology and cognition can be moderated by frailty. Methods: We included 1711 participants from the Alzheimer’s Disease Neuroimaging Initiative database. Levels of cerebrospinal fluid amyloid-β, p-tau, and t-tau were identified for AD-related pathology based on the amyloid-β/tau/neurodegeneration (AT[N]) framework. Frailty was measured using a modified Frailty Index-11 (mFI-11). Regression and interaction models were utilized to assess the relationship among frailty, AT(N) profiles, and cognition. Moderation models analyzed the correlation between AT(N) profiles and cognition across three frailty levels. All analyses were corrected for age, sex, education, and APOE ɛ4 status. Results: In this study, frailty (odds ratio [OR] = 1.71, p 
ISSN:1387-2877
1875-8908
1875-8908
DOI:10.3233/JAD-231489