Restoring initial steps by intermittent theta burst stimulation in complete spinal cord injury patient: a case report

Introduction Spinal cord injury (SCI) causes damage to neurons and results in motor and sensory dysfunction. Intermittent theta burst stimulation (iTBS) has been used to induce neuronal and synaptic plasticity by applying a magnetic field in the brain. The plasticity induced in the cortex has an imp...

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Bibliographic Details
Published in:Spinal cord series and cases 2024-08, Vol.10 (1), p.56, Article 56
Main Authors: Patel, Deeksha, Banerjee, Rohit, Farooque, Kamran, Gupta, Deepak, Garg, Bhavuk, Kumar, Nand, Thukral, Gita H., Kochhar, Kanwal Preet, Jain, Suman
Format: Article
Language:English
Subjects:
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Adult
Anatomy
Biomedical and Life Sciences
Biomedicine
Case Report
Case reports
Female
Human Physiology
Humans
Motor Cortex
Neurochemistry
Neuropsychology
Neurosciences
Recovery of Function - physiology
Spinal cord injuries
Spinal Cord Injuries - complications
Spinal Cord Injuries - physiopathology
Spinal Cord Injuries - rehabilitation
Spinal Cord Injuries - therapy
Theta Rhythm - physiology
Transcranial Magnetic Stimulation - methods
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Summary:Introduction Spinal cord injury (SCI) causes damage to neurons and results in motor and sensory dysfunction. Intermittent theta burst stimulation (iTBS) has been used to induce neuronal and synaptic plasticity by applying a magnetic field in the brain. The plasticity induced in the cortex has an imperative role in the recovery of motor and sensory functioning. However, the effect of iTBS in complete SCI patients is still elusive. Case presentation We report here the case of a 27-year-old female who sustained an L1 complete spinal cord injury (SCI) with an ASIA score of A. The patient lost all the sensory and motor functions below the level of injury. Intermittent theta burst stimulation (iTBS) was administered at 80% of the resting motor threshold over the M1 motor cortex, along with intensive rehabilitation training to promote sensorimotor function. Discussion There was a partial recovery in functional, electrophysiological, and neurological parameters. The case report also demonstrates the safety and efficacy of iTBS in complete SCI patients. No adverse event has been observed in the patient during intervention sessions.
ISSN:2058-6124
2058-6124
DOI:10.1038/s41394-024-00669-8