Dimethyl sulfoxide, an alternative for control of Nosema ceranae infection in honey bees (Apis mellifera)

Nosema ceranae is a microsporidian parasite that threatens current apiculture. N. ceranae‐infected honey bees (Apis mellifera) exhibit morbid physiological impairments and reduced honey production, malnutrition, shorter life span, and higher mortality than healthy honey bees. In this study, we found...

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Bibliographic Details
Published in:Archives of insect biochemistry and physiology 2024-08, Vol.116 (4), p.e22099-n/a
Main Authors: Ho, Shang‐Tse, Nai, Yu‐Shin, Chang, Zih‐Ting, Chang, Ju‐Chun, Hsu, Wei‐Chen, Ko, Chung‐Yu, Chen, Yue‐Wen, Yang, Yu‐Liang
Format: Article
Language:English
Subjects:
Animals
Apiculture
Apis mellifera
Beekeeping
Bees
Bees - microbiology
comparative RNA sequencing
Dimethyl sulfoxide
Dimethyl Sulfoxide - pharmacology
DMSO
Gene sequencing
Honey
Infections
Life span
Malnutrition
Metabolism
Microsporidiosis - veterinary
Nosema - drug effects
Nosema - physiology
Nosema ceranae
Parasites
Sequence analysis
Sulfoxides
Survival
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Summary:Nosema ceranae is a microsporidian parasite that threatens current apiculture. N. ceranae‐infected honey bees (Apis mellifera) exhibit morbid physiological impairments and reduced honey production, malnutrition, shorter life span, and higher mortality than healthy honey bees. In this study, we found that dimethyl sulfoxide (DMSO) could enhance the survival rate of N. ceranae‐infected honey bees. Therefore, we investigated the effect of DMSO on N. ceranae‐infected honey bees using comparative RNA sequencing analysis. Our results revealed that DMSO was able to affect several biochemical pathways, especially the metabolic‐related pathways in N. ceranae‐infected honey bees. Based on these findings, we conclude that DMSO may be a useful alternative for treating N. ceranae infection in apiculture. Dimethyl sulfoxide (DMSO) has the potential to improve the survival rate of honey bees infected with Nosema ceranae, making it a promising option for future applications in apiculture. Research highlight Dimethyl sulfoxide (DMSO) could enhance the survival rate of Nosema ceranae‐infected honey bees. DMSO was able to affect several biochemical pathways, especially the metabolic‐related pathways in N. ceranae‐infected honey bees. Our study demonstrated that DMSO may become a reasonable alternative for treating N. ceranae infection in apiculture in the future.
ISSN:0739-4462
1520-6327
1520-6327
DOI:10.1002/arch.22099