New paradigms to break barriers in early cancer detection for improved prognosis and treatment outcomes

• Published in: The journal of gene medicine 2024-08, Vol.26 (8), p.e3730-n/a
• Main Authors: Ahmad, Irfan, Jasim, Saade Abdalkareem, Sharma, M. K., S, Renuka Jyothi, Hjazi, Ahmed, Mohammed, Jaafaru Sani, Sinha, Aashna, Zwamel, Ahmed Hussein, Hamzah, Hamza Fadhel, Mohammed, Bahira Abdulrazzaq
• Format: Article
• Language: English
• Subjects: Biomarkers, Tumor - genetics; cancer; Cancer screening; Cancer therapies; Cell death; Diagnosis; Early Detection of Cancer - methods; Humans; Neoplasms - diagnosis; Neoplasms - genetics; Neoplasms - therapy; Prognosis; treatment; Treatment Outcome
• ISSN: 1099-498X; 1521-2254; 1521-2254
• DOI: 10.1002/jgm.3730

The uncontrolled growth and spread of cancerous cells beyond their usual boundaries into surrounding tissues characterizes cancer. In developed countries, cancer is the leading cause of death, while in underdeveloped nations, it ranks second. Using existing cancer diagnostic tools has increased early detection rates, which is crucial for effective cancer treatment. In recent decades, there has been significant progress in cancer‐specific survival rates owing to advances in cancer detection and treatment. The ability to accurately identify precursor lesions is a crucial aspect of effective cancer screening programs, as it enables early treatment initiation, leading to lower long‐term incidence of invasive cancer and improved overall prognosis. However, these diagnostic methods have limitations, such as high costs and technical challenges, which can make accurate diagnosis of certain deep‐seated tumors difficult. To achieve accurate cancer diagnosis and prognosis, it is essential to continue developing cutting‐edge technologies in molecular biology and cancer imaging. The uncontrolled invasion of cancer cells into adjacent tissues poses a considerable clinical challenge. Cancer is the leading cause of mortality in developed nations and the second leading cause in underdeveloped regions. Early detection is critical, and recent advancements in diagnostic techniques have improved patient survival rates. Identifying precursor lesions is essential for effective screening and treatment. However, existing diagnostic approaches are hindered by high costs and technical complexities. Therefore, the continuous progress of advanced molecular biology and imaging technologies is vital for improving cancer diagnosis and prognosis.