Evolving immunotherapeutic solutions for triple-negative breast carcinoma

• Published in: Cancer treatment reviews 2024-11, Vol.130, p.102817, Article 102817
• Main Authors: Wu, Shiting, Ge, Anqi, Deng, Xianguang, Liu, Lifang, Wang, Yue
• Format: Article
• Language: English
• Subjects: Immune checkpoint inhibitors; Immunotherapy; Therapeutic modality; Triple-negative breast carcinoma; Tumor microenvironment
• ISSN: 0305-7372; 1532-1967; 1532-1967
• DOI: 10.1016/j.ctrv.2024.102817

[Display omitted] •Evolving immunotherapy provides hope in TNBC complexities.•Diverse TNBC microenvironments advocate personalized immunotherapeutic strategies.•ICIs demonstrate efficacy alone or in synergy with established treatments.•Combining ICIs with targeted therapies enhances TNBC management.•Vaccines, cellular immunotherapy, and oncolytic viruses hold TNBC treatment promise. Triple-negative breast carcinoma (TNBC) remains a formidable clinical hurdle owing to its high aggressiveness and scant therapeutic options. Nonetheless, the evolving landscape of immunotherapeutic strategies opens up promising avenues for tackling this hurdle. This review discusses the advancing immunotherapy for TNBC, accentuating personalized interventions due to tumor microenvironment (TME) diversity. Immune checkpoint inhibitors (ICIs) hold pivotal significance, both as single-agent therapies and when administered alongside cytotoxic agents. Moreover, the concurrent inhibition of multiple immune checkpoints represents a potent approach to augment the efficacy of cancer immunotherapy. Synergistic effects have been observed when ICIs are combined with targeted treatments like PARP inhibitors, anti-angiogenics, and ADCs (antibody-drug conjugates). Emerging tactics include tumor vaccines, cellular immunotherapy, and oncolytic viruses, leveraging the immune system’s ability for selective malignant cell destruction. This review offers an in-depth examination of the diverse landscape of immunotherapy development for TNBC, furnishing meticulous insights into various advancements within this field. In addition, immunotherapeutic interventions offer hope for TNBC, needing further research for optimization.