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Transcriptional signatures of cortical structural changes in chronic insomnia disorder
Chronic insomnia disorder (CID) is a multidimensional disease that may influence various levels of brain organization, spanning the macroscopic structural connectome to microscopic gene expression. However, the connection between genomic variations and morphological alterations in CID remains unclea...
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| Published in: | Psychophysiology 2024-12, Vol.61 (12), p.e14671-n/a |
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| container_title | Psychophysiology |
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| creator | Yu, Liyong Hu, Daijie Luo, Yucai Lin, Wenting Xu, Hao Xiao, Xiangwen Xia, Zihao Dou, Zeyang Zhao, Guangli Yang, Lu Peng, Dezhong Zhang, Qi Yu, Siyi |
| description | Chronic insomnia disorder (CID) is a multidimensional disease that may influence various levels of brain organization, spanning the macroscopic structural connectome to microscopic gene expression. However, the connection between genomic variations and morphological alterations in CID remains unclear. Here, we investigated brain structural changes in CID patients at the whole‐brain level and whether these link to transcriptional characteristics. Brain structural data from 104 CID patients and 102 matched healthy controls (HC) were acquired to examine cortical structural alterations using morphometric similarity (MS) analysis. Partial least squares (PLS) regression and transcriptome data from the Allen Human Brain Atlas were used to extract genomes related to MS changes. Gene‐category enrichment analysis (GCEA) was used to identify potential molecular mechanisms behind the observed structural changes. We found that CID patients exhibited MS reductions in the parietal and limbic regions, along with enhancements in the temporal and frontal regions compared to HCs (pFDR |
| doi_str_mv | 10.1111/psyp.14671 |
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The association between genomics and brain structural changes in chronic insomnia disorder is not well understood. Imaging transcriptional analysis bridges the gap between cortical structural changes and molecular mechanisms. Integrating neuroimaging and gene expression data, our work indicates that structural changes in chronic insomnia may be related to chronic neuroinflammation and imbalances between excitatory and inhibitory neuronal activities.</description><identifier>ISSN: 0048-5772</identifier><identifier>ISSN: 1469-8986</identifier><identifier>EISSN: 1469-8986</identifier><identifier>EISSN: 1540-5958</identifier><identifier>DOI: 10.1111/psyp.14671</identifier><identifier>PMID: 39160694</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Brain architecture ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; chronic Insomnia disorder ; Female ; Gene expression ; Humans ; Insomnia ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Molecular modelling ; morphometric similarity ; Neuroimaging ; Physical characteristics ; sleep < content/topics ; Sleep disorders ; Sleep Initiation and Maintenance Disorders - diagnostic imaging ; Sleep Initiation and Maintenance Disorders - genetics ; Sleep Initiation and Maintenance Disorders - pathology ; Transcriptome ; Transcriptomes ; Transcriptomics</subject><ispartof>Psychophysiology, 2024-12, Vol.61 (12), p.e14671-n/a</ispartof><rights>2024 Society for Psychophysiological Research.</rights><rights>Copyright © 2024 by the Society for Psychophysiological Research</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2461-abae1b95b4ea2b8225710be05df3e7ef72bd8cf45d800a710fca14c495628ea03</cites><orcidid>0000-0002-2916-1903</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39160694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Liyong</creatorcontrib><creatorcontrib>Hu, Daijie</creatorcontrib><creatorcontrib>Luo, Yucai</creatorcontrib><creatorcontrib>Lin, Wenting</creatorcontrib><creatorcontrib>Xu, Hao</creatorcontrib><creatorcontrib>Xiao, Xiangwen</creatorcontrib><creatorcontrib>Xia, Zihao</creatorcontrib><creatorcontrib>Dou, Zeyang</creatorcontrib><creatorcontrib>Zhao, Guangli</creatorcontrib><creatorcontrib>Yang, Lu</creatorcontrib><creatorcontrib>Peng, Dezhong</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Yu, Siyi</creatorcontrib><title>Transcriptional signatures of cortical structural changes in chronic insomnia disorder</title><title>Psychophysiology</title><addtitle>Psychophysiology</addtitle><description>Chronic insomnia disorder (CID) is a multidimensional disease that may influence various levels of brain organization, spanning the macroscopic structural connectome to microscopic gene expression. However, the connection between genomic variations and morphological alterations in CID remains unclear. Here, we investigated brain structural changes in CID patients at the whole‐brain level and whether these link to transcriptional characteristics. Brain structural data from 104 CID patients and 102 matched healthy controls (HC) were acquired to examine cortical structural alterations using morphometric similarity (MS) analysis. Partial least squares (PLS) regression and transcriptome data from the Allen Human Brain Atlas were used to extract genomes related to MS changes. Gene‐category enrichment analysis (GCEA) was used to identify potential molecular mechanisms behind the observed structural changes. We found that CID patients exhibited MS reductions in the parietal and limbic regions, along with enhancements in the temporal and frontal regions compared to HCs (pFDR < .05). Subsequently, PLS and GCEA revealed that these MS alterations were spatially correlated with a set of genes, especially those significantly correlated with excitatory and inhibitory neurons and chronic neuroinflammation. This neuroimaging‐transcriptomic study bridges the gap between cortical structural changes and the molecular mechanisms in CID patients, providing novel insight into the pathophysiology of insomnia and targeted treatments.
The association between genomics and brain structural changes in chronic insomnia disorder is not well understood. Imaging transcriptional analysis bridges the gap between cortical structural changes and molecular mechanisms. Integrating neuroimaging and gene expression data, our work indicates that structural changes in chronic insomnia may be related to chronic neuroinflammation and imbalances between excitatory and inhibitory neuronal activities.</description><subject>Adult</subject><subject>Brain architecture</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>chronic Insomnia disorder</subject><subject>Female</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Insomnia</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular modelling</subject><subject>morphometric similarity</subject><subject>Neuroimaging</subject><subject>Physical characteristics</subject><subject>sleep < content/topics</subject><subject>Sleep disorders</subject><subject>Sleep Initiation and Maintenance Disorders - diagnostic imaging</subject><subject>Sleep Initiation and Maintenance Disorders - genetics</subject><subject>Sleep Initiation and Maintenance Disorders - pathology</subject><subject>Transcriptome</subject><subject>Transcriptomes</subject><subject>Transcriptomics</subject><issn>0048-5772</issn><issn>1469-8986</issn><issn>1469-8986</issn><issn>1540-5958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kM1KxDAUhYMozji68QGk4EaEapKmbbKUwT8YcMBRcBXSNB0ztElNWmTe3tSOLlx4N_dw78eBcwA4RfAKhblu_ba9QiTL0R6Yhs1iymi2D6YQEhqneY4n4Mj7DYSQIYwPwSRhKIMZI1PwunLCeOl022lrRB15vTai653yka0iaV2n5XDuXC_DOUj5Lsw6vLUJ0lmjZZDeNkaLqNTeulK5Y3BQidqrk92egZe729X8IV483T_ObxaxxCRDsSiEQgVLC6IELijGaY5goWBaVonKVZXjoqSyImlJIRThV0mBiCQszTBVAiYzcDH6ts5-9Mp3vNFeqroWRtne8wQyQvEQO6Dnf9CN7V2IHCiUIIhxluaBuhwp6az3TlW8dboRbssR5EPbfGibf7cd4LOdZV80qvxFf-oNABqBT12r7T9WfPn8thxNvwCL4ovP</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Yu, Liyong</creator><creator>Hu, Daijie</creator><creator>Luo, Yucai</creator><creator>Lin, Wenting</creator><creator>Xu, Hao</creator><creator>Xiao, Xiangwen</creator><creator>Xia, Zihao</creator><creator>Dou, Zeyang</creator><creator>Zhao, Guangli</creator><creator>Yang, Lu</creator><creator>Peng, Dezhong</creator><creator>Zhang, Qi</creator><creator>Yu, Siyi</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2916-1903</orcidid></search><sort><creationdate>202412</creationdate><title>Transcriptional signatures of cortical structural changes in chronic insomnia disorder</title><author>Yu, Liyong ; Hu, Daijie ; Luo, Yucai ; Lin, Wenting ; Xu, Hao ; Xiao, Xiangwen ; Xia, Zihao ; Dou, Zeyang ; Zhao, Guangli ; Yang, Lu ; Peng, Dezhong ; Zhang, Qi ; Yu, Siyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2461-abae1b95b4ea2b8225710be05df3e7ef72bd8cf45d800a710fca14c495628ea03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Brain architecture</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>chronic Insomnia disorder</topic><topic>Female</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Insomnia</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular modelling</topic><topic>morphometric similarity</topic><topic>Neuroimaging</topic><topic>Physical characteristics</topic><topic>sleep < content/topics</topic><topic>Sleep disorders</topic><topic>Sleep Initiation and Maintenance Disorders - diagnostic imaging</topic><topic>Sleep Initiation and Maintenance Disorders - genetics</topic><topic>Sleep Initiation and Maintenance Disorders - pathology</topic><topic>Transcriptome</topic><topic>Transcriptomes</topic><topic>Transcriptomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Liyong</creatorcontrib><creatorcontrib>Hu, Daijie</creatorcontrib><creatorcontrib>Luo, Yucai</creatorcontrib><creatorcontrib>Lin, Wenting</creatorcontrib><creatorcontrib>Xu, Hao</creatorcontrib><creatorcontrib>Xiao, Xiangwen</creatorcontrib><creatorcontrib>Xia, Zihao</creatorcontrib><creatorcontrib>Dou, Zeyang</creatorcontrib><creatorcontrib>Zhao, Guangli</creatorcontrib><creatorcontrib>Yang, Lu</creatorcontrib><creatorcontrib>Peng, Dezhong</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Yu, Siyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Psychophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Liyong</au><au>Hu, Daijie</au><au>Luo, Yucai</au><au>Lin, Wenting</au><au>Xu, Hao</au><au>Xiao, Xiangwen</au><au>Xia, Zihao</au><au>Dou, Zeyang</au><au>Zhao, Guangli</au><au>Yang, Lu</au><au>Peng, Dezhong</au><au>Zhang, Qi</au><au>Yu, Siyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptional signatures of cortical structural changes in chronic insomnia disorder</atitle><jtitle>Psychophysiology</jtitle><addtitle>Psychophysiology</addtitle><date>2024-12</date><risdate>2024</risdate><volume>61</volume><issue>12</issue><spage>e14671</spage><epage>n/a</epage><pages>e14671-n/a</pages><issn>0048-5772</issn><issn>1469-8986</issn><eissn>1469-8986</eissn><eissn>1540-5958</eissn><abstract>Chronic insomnia disorder (CID) is a multidimensional disease that may influence various levels of brain organization, spanning the macroscopic structural connectome to microscopic gene expression. However, the connection between genomic variations and morphological alterations in CID remains unclear. Here, we investigated brain structural changes in CID patients at the whole‐brain level and whether these link to transcriptional characteristics. Brain structural data from 104 CID patients and 102 matched healthy controls (HC) were acquired to examine cortical structural alterations using morphometric similarity (MS) analysis. Partial least squares (PLS) regression and transcriptome data from the Allen Human Brain Atlas were used to extract genomes related to MS changes. Gene‐category enrichment analysis (GCEA) was used to identify potential molecular mechanisms behind the observed structural changes. We found that CID patients exhibited MS reductions in the parietal and limbic regions, along with enhancements in the temporal and frontal regions compared to HCs (pFDR < .05). Subsequently, PLS and GCEA revealed that these MS alterations were spatially correlated with a set of genes, especially those significantly correlated with excitatory and inhibitory neurons and chronic neuroinflammation. This neuroimaging‐transcriptomic study bridges the gap between cortical structural changes and the molecular mechanisms in CID patients, providing novel insight into the pathophysiology of insomnia and targeted treatments.
The association between genomics and brain structural changes in chronic insomnia disorder is not well understood. Imaging transcriptional analysis bridges the gap between cortical structural changes and molecular mechanisms. Integrating neuroimaging and gene expression data, our work indicates that structural changes in chronic insomnia may be related to chronic neuroinflammation and imbalances between excitatory and inhibitory neuronal activities.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>39160694</pmid><doi>10.1111/psyp.14671</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-2916-1903</orcidid></addata></record> |
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| subjects | Adult Brain architecture Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology chronic Insomnia disorder Female Gene expression Humans Insomnia Magnetic Resonance Imaging Male Middle Aged Molecular modelling morphometric similarity Neuroimaging Physical characteristics sleep < content/topics Sleep disorders Sleep Initiation and Maintenance Disorders - diagnostic imaging Sleep Initiation and Maintenance Disorders - genetics Sleep Initiation and Maintenance Disorders - pathology Transcriptome Transcriptomes Transcriptomics |
| title | Transcriptional signatures of cortical structural changes in chronic insomnia disorder |
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