Neural correlates of anxiety in adult-onset isolated dystonia

• Published in: Neuroscience 2024-10, Vol.558, p.50-57
• Main Authors: Yang, Zhengkun, Liu, Huiming, Zhang, Jiana, Luo, Yuhan, Weng, Ai, Zhang, Yue, Zhong, Linchang, Ou, Zilin, Yan, Zhicong, Zhang, Weixi, Peng, Kangqiang, Xu, Jinping, Liu, Gang
• Format: Article
• Language: English
• Subjects: Adult-onset isolated dystonia; Anxiety; Receiver operating characteristic curve; Resting-state fMRI; Structural MRI
• ISSN: 0306-4522; 1873-7544; 1873-7544
• DOI: 10.1016/j.neuroscience.2024.08.018

[Display omitted] •Functional neuroimaging alterations in AOID patients with anxiety.•Correlations analysis support neural basis of anxiety symptoms in AOID.•Candidate imaging biomarkers to distinguish AOID patients with/without anxiety. Psychiatric disturbances are commonly associated with adult-onset isolated dystonia (AOID); however, the mechanisms underlying psychiatric abnormalities in AOID remain unknown. We aimed to investigate the structural and functional brain changes in AOID patients with anxiety, and identify imaging biomarkers for diagnosing anxiety. Structural and functional magnetic resonance was performed on 69 AOID patients and 35 healthy controls (HCs). The Hamilton Anxiety Scale (HAMA) was used to assess anxiety symptoms in AOID patients and assign patients to AOID with and without anxiety groups. Group differences in grey matter volume, amplitude of low-frequency fluctuations (ALFF), fractional ALFF, and regional homogeneity (ReHo) were evaluated. Area under the receiver operating characteristic curve (ROC AUC) was used as a metric to identify imaging biomarkers for diagnosing anxiety. AOID patients with anxiety exhibited an increased ALFF and ReHo in the left angular gyrus (ANG.L) compared with those without and HCs (voxel P