Deep learning-based automated liver contouring using a small sample of radiotherapy planning computed tomography images

• Published in: Radiography (London, England. 1995) England. 1995), 2024-08, Vol.30 (5), p.1442-1450
• Main Authors: Arjmandi, N., Momennezhad, M., Arastouei, S., Mosleh-Shirazi, M.A., Albawi, A., Pishevar, Z., Nasseri, S.
• Format: Article
• Language: English
• Subjects: Attention U-Net; CT images; Deep Learning; Feasibility Studies; Humans; Liver - diagnostic imaging; Liver contouring; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - radiotherapy; Radiotherapy Planning, Computer-Assisted - methods; Residual; Tomography, X-Ray Computed - methods; Training size
• ISSN: 1078-8174; 1532-2831; 1532-2831
• DOI: 10.1016/j.radi.2024.08.005

No study has yet investigated the minimum amount of data required for deep learning-based liver contouring. Therefore, this study aimed to investigate the feasibility of automated liver contouring using limited data. Radiotherapy planning Computed tomography (CT) images were subjected to various preprocessing methods, such as denoising and windowing. Segmentation was conducted using the modified Attention U-Net and Residual U-Net networks. Two different modified networks were trained separately for different training sizes. For each architecture, the model trained with the training set size that achieved the highest dice similarity coefficient (DSC) score was selected for further evaluation. Two unseen external datasets with different distributions from the training set were also used to examine the generalizability of the proposed method. The modified Residual U-Net and Attention U-Net networks achieved average DSCs of 97.62% and 96.48%, respectively, on the test set, using 62 training cases. The average Hausdorff distances (AHDs) for the modified Residual U-Net and Attention U-Net networks were 0.57 mm and 0.71 mm, respectively. Also, the modified Residual U-Net and Attention U-Net networks were tested on two unseen external datasets, achieving DSCs of 95.35% and 95.82% for data from another center and 95.16% and 94.93% for the AbdomenCT-1K dataset, respectively. This study demonstrates that deep learning models can accurately segment livers using a small training set. The method, utilizing simple preprocessing and modified network architectures, shows strong performance on unseen datasets, indicating its generalizability. This promising result suggests its potential for automated liver contouring in radiotherapy planning.