Magnetically actuated cisplatin-loaded nanoparticle collectives enhance drug penetration for potentiated ovarian cancer chemotherapy

• Published in: Journal of colloid and interface science 2025-01, Vol.678 (Pt A), p.108-118
• Main Authors: Chen, Ying, Zhang, Qiang, Shen, Jian, Liu, Zhiran, Cui, Xiaoyu, Ma, Li, Zheng, Yuanyi, Wang, Longchen, Ying, Tao
• Format: Article
• Language: English
• Subjects: Drug delivery; Magnetic nanoparticles; Ovarian cancer; Tumor penetration
• ISSN: 0021-9797; 1095-7103; 1095-7103
• DOI: 10.1016/j.jcis.2024.08.160

We propose a strategy utilizing magnetic nanoparticle collectives to enhance drug targeted delivery and penetration for potentiated ovarian cancer chemotherapy. The designed magnetic pH-responsive nanoparticle collectives could active deliver chemotherapeutics to the tumor site, and enhance drug penetration into deep tumors by the torque-force hybrid magnetic field, offering potentially clinically feasible strategy for enhancing tumor chemotherapy. [Display omitted] Chemotherapy is the main clinical treatment for ovarian cancer, but still faces challenges of low drug targeting efficiency and insufficient drug permeability. Drug-loaded nanoparticle collectives, which are actuated by magnetic field, could be targeted to a designated location and achieve targeted drug delivery. In this work, we report a strategy that utilizes magnetic mesoporous silica nanoparticles loaded with cis-diaminodichloroplatinum (Fe3O4@SiO2-CDDP) for targeted delivery of chemotherapeutic drugs and enhances penetration into deep tumors. The Fe3O4@SiO2-CDDP collectives actively moved to the target tumor site, and this movement was regulated by a magnetic actuation system. Under the action of a torque-force hybrid magnetic field (TFMF), Fe3O4@SiO2-CDDP could further penetrate into the interior of tumors and achieve pH-responsive drug release in the tumor environment. The feasibility of this strategy was verified in three-dimensional cell spheres in vitro and in a tumor-bearing mouse model in vivo. This magnetically actuated nanoparticle collectives enhanced drug penetration strategy provides a new paradigm for targeted drug delivery and potentiated tumor therapy.