On the role of antibody affinity and avidity in the IgE-mediated allergic response

Type I hypersensitivity, also known as classical allergy, is mediated via allergen-specific IgE antibodies bound to type I FcR (FcεRI) on the surface of mast cells and basophils upon cross-linking by allergens. This IgE-mediated cellular activation may be blocked by allergen-specific IgG through mul...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2024-08
Main Authors: Bachmann, Martin F, Krenger, Pascal S, Mohsen, Mona O, Kramer, Matthias F, Starchenka, Sviatlana, Whitehead, Piers, Vogel, Monique, Heath, Matthew D
Format: Article
Language:English
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Summary:Type I hypersensitivity, also known as classical allergy, is mediated via allergen-specific IgE antibodies bound to type I FcR (FcεRI) on the surface of mast cells and basophils upon cross-linking by allergens. This IgE-mediated cellular activation may be blocked by allergen-specific IgG through multiple mechanisms, including direct neutralization of the allergen or engagement of the inhibitory receptor FcγRIIb which blocks IgE signal transduction. In addition, co-engagement of FcεRI and FcγRIIb by IgE-IgG-allergen immune complexes causes down regulation of receptor-bound IgE, resulting in desensitization of the cells. Both, activation of FcεRI by allergen-specific IgE and engagement of FcγRIIb by allergen-specific IgG are driven by allergen-binding. Here we delineate the distinct roles of antibody affinity versus avidity in driving these processes and discuss the role of IgG subclasses in inhibiting basophil and mast cell activation.
ISSN:1398-9995
1398-9995
DOI:10.1111/all.16248