Intra-uterine injection of amnion-derived acellular bioscaffold product in mares, a description of systemic and intra-uterine effects over 21 days

•Amnion-derived acellular bioscaffold product injected intrauterine had no negative effects. Amnion-derived acellular bioscaffold (ADABP) products demonstrate interesting anti-inflammatory and healing properties which could be beneficial for intrauterine use. The objective of this study was to evalu...

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Bibliographic Details
Published in:Journal of equine veterinary science 2024-11, Vol.142, p.105180, Article 105180
Main Authors: Kelley, Dale, Walbornn, Stephanie, Bartley, Christine, Kaczor, Jamie, Premanandan, Christopher, Newton, Nathaniel, Holland, Robert, Schnobrich, Maria
Format: Article
Language:English
Subjects:
Amnion
Animals
Endometrial biopsy
Female
Horses
Injections
Mare
safety
Uterus - pathology
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Summary:•Amnion-derived acellular bioscaffold product injected intrauterine had no negative effects. Amnion-derived acellular bioscaffold (ADABP) products demonstrate interesting anti-inflammatory and healing properties which could be beneficial for intrauterine use. The objective of this study was to evaluate the safety of intrauterine injection of ADABP on systemic and uterine health. The study design randomly assigned subjects to one of two groups, control mares (n = 3) which received 3 mL injection of sterile saline in the base of each uterine horn, and treatment mares (n = 9) which received 3 mL of ADABP in the base of one uterine horn and 3 mL injection of sterile saline in the base of the other uterine horn. The leukogram had no significant effect of group and no group by day interaction. The serum biochemistry panel had no effect of group on any of the parameters examined. There were no significant differences in uterine culture or uterine biopsy results. The data suggests intrauterine injection of ADABP has no negative systemic or uterine effects.
ISSN:0737-0806
DOI:10.1016/j.jevs.2024.105180