Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models

Myocardial injury may ultimately lead to adverse ventricular remodeling and development of heart failure (HF), which is a major cause of morbidity and mortality worldwide. Given the slow pace and substantial costs of developing new therapeutics, drug repurposing is an attractive alternative. Studies...

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Bibliographic Details
Published in:	Nature Cardiovascular Research 2024-09, Vol.3 (9), p.1049-1066
Main Authors:	Aviel, Gal, Elkahal, Jacob, Umansky, Kfir Baruch, Bueno-Levy, Hanna, Petrover, Zachary, Kotlovski, Yulia, Lendengolts, Daria, Kain, David, Shalit, Tali, Zhang, Lingling, Miyara, Shoval, Kramer, Matthias P., Merbl, Yifat, Kozlovski, Stav, Alon, Ronen, Aharoni, Rina, Arnon, Ruth, Mishali, David, Katz, Uriel, Nachman, Dean, Asleh, Rabea, Amir, Offer, Tzahor, Eldad, Sarig, Rachel
Format:	Article
Language:	English
Subjects:	Animals Cardiac function Cardiovascular disease Cells, Cultured Disease Models, Animal Drug Repositioning Drugs Glatiramer Acetate - pharmacology Glatiramer Acetate - therapeutic use Heart Heart Failure - drug therapy Ischemia Male Mice Mice, Inbred C57BL Mortality Myocardial Infarction - drug therapy Myocardial Infarction - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology Neovascularization, Physiologic - drug effects Rats Rats, Sprague-Dawley T cell receptors Ventricular Function, Left - drug effects Ventricular Remodeling - drug effects
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