Antibacterial and Antileishmanial Activity of 1,4-Dihydropyridine Derivatives

• Published in: Chemistry & biodiversity 2024-10, p.e202401300
• Main Authors: Oliveira, Thaís A S, Silva, Jackson B A, Silva, Nagela B S, Félix, Paulo C A, Dos Santos, Daiane A, de Oliveira, Andreia M, Martins, Carlos H G, Magalhães, Lizandra G, Crotti, Antônio E M
• Format: Article
• Language: English
• ISSN: 1612-1872; 1612-1880; 1612-1880
• DOI: 10.1002/cbdv.202401300

We have synthesized twenty-three 1,4-dihydropyridine derivatives (1,4-DHPs) by using a microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their antibacterial activity against a representative panel of cariogenic bacteria and their in vitro antileishmanial activity against Leishmania (L.) amazonensis promastigotes and amastigotes. Thirteen compounds were moderately active against Streptococcus sanguinis, Streptococcus mitis, and Lactobacillus paracasei. Compound 22 (diethyl 4-(3-methoxy-4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate) displayed moderate antibacterial activity against S. mitis and S. sanguinis, with a Minimum Inhibitory Concentration (MIC) of 500 μg/mL); compounds 8 (ethyl 2,7,7-trimethyl-4-(3-chlorophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate) and 10 (ethyl 2,7,7-trimethyl-4-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate) were moderately active against S. sanguinis (MIC=500 μg/mL) and very active against L. amazonensis promastigotes (IC =43.08 and 34.29 μM, respectively). Among the eight 1,4-DHPs that were active (IC 7.9 and >7.3, respectively) after 24 h of treatment. Our results indicated that asymmetric 1,4-DHPs derived from dimedone exhibit antileishmanial potential.