Long term safety and outcomes after atrial shunting for heart failure with preserved or mildly reduced ejection fraction: 5-year and 3-year follow-up in the REDUCE LAP-HF I and II trials

There is a little evidence regarding long-term safety and efficacy for atrial shunt devices in heart failure (HF). The REDUCE LAP-HF I (n = 44) and II (n = 621) trials (RCT-I and -II) were multicenter, randomized, sham-controlled trials of patients with HF and ejection fraction >40%. Outcome data...

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Bibliographic Details
Published in:The American heart journal 2024-12, Vol.278, p.106-116
Main Authors: Litwin, Sheldon E., Komtebedde, Jan, Borlaug, Barry A., Kaye, David M., Hasenfuβ, Gerd, Kawash, Rami, Hoendermis, Elke, Hummel, Scott L., Cikes, Maja, Gustafsson, Finn, Chung, Eugene S., Mohan, Rajeev C., Sverdlov, Aaron L., Swarup, Vijendra, Winkler, Sebastian, Hayward, Christopher S., Bergmann, Martin W., Bugger, Heiko, McKenzie, Scott, Nair, Ajith, Rieth, Andreas, Burkhoff, Daniel, Cutlip, Donald E., Solomon, Scott D., van Veldhuisen, Dirk J., Leon, Martin B., Shah, Sanjiv J.
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - physiopathology
Atrial Fibrillation - surgery
Cardiovascular diseases
Clinical trials
Congestive heart failure
Diuretics
Ejection fraction
Emergency medical care
Female
Follow-Up Studies
Heart Atria - physiopathology
Heart failure
Heart Failure - physiopathology
Heart Failure - surgery
Humans
Ischemia
Kidney diseases
Male
Middle Aged
Mortality
Patient safety
Patients
Regression analysis
Shunts
Stroke
Stroke - epidemiology
Stroke - etiology
Stroke - prevention & control
Stroke Volume - physiology
Surgical outcomes
Time Factors
Treatment Outcome
Citations: Items that this one cites
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Description
Summary:There is a little evidence regarding long-term safety and efficacy for atrial shunt devices in heart failure (HF). The REDUCE LAP-HF I (n = 44) and II (n = 621) trials (RCT-I and -II) were multicenter, randomized, sham-controlled trials of patients with HF and ejection fraction >40%. Outcome data were analyzed from RCT-I, a mechanistic trial with 5-year follow-up, and RCT-II, a pivotal trial identifying a responder group (n = 313) defined by exercise PVR
ISSN:0002-8703
1097-6744
1097-6744
DOI:10.1016/j.ahj.2024.08.014